Comparison of Preeclampsian Pregnancy by Metabolic Components

Authors

  • Yulia Margaretta Sari Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Joserizal Serudji Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Rizanda Machmud Public Health Department, Faculty of Medicine, Andalas University Padang

DOI:

https://doi.org/10.25077/aoj.3.2.116-129.2019

Abstract

In preeclampsia occurring carbohydrate and fat metabolism disorders. Components of the metabolic syndrome such as insulin resistance, obesity, and dyslipidemia contributes to the occurrence of preeclampsia. This was an obser-vational analytic study with Kohort design and has been performed in Obgyn Department of M. Djamil Hospital Padang, primary health care in Koto Berapak, Private Practice Midwive in Lintau from July 2013 to May 2014. 60 samples of second trimester of pregnancy with positive Roll over test. Each subject was examined BMI, fasting blood glucose, LDL, HDL, triglycerides, and insulin levels. Then divided into two groups, positive metabolic components group and negative metabolic components group. Statistical analysis to assess significance using the unpaired t test and chi square on SPSS 18.0 for windows. There was no significant association between metabolic components and preeclampsia (p> 0.05). Other metabolic components such as HDL level and insulin resistance were not statistically significant with preeclampsia (p> 0.05). HOMA IR examination also showed no significant association with the in-cidence of preeclampsia. However, the subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05). subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05). subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05).

Keywords: Preeclampsia, metabolic syndrome, fasting blood glucose, LDL, HDL, triglycerides, HOMA-IR, BMI

Author Biography

Joserizal Serudji, Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang

Bagian Obstetri dan Ginekologi
Fakultas Kedokteran Universitas Andalas Padang

References

Eiland E, Nzerue C, Faulkner M. Preeclampsia 2012. Journal of Pregnancy Volume 2012

Jie L, et al. A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia. Chinese Medical Journal, 2011; 124(5): 775-779

Madi J, dan Sulin D. Angka kematian Pasien preeklampsia dan Eklampsia RS Dr M Djamil padang tahun 1998-2002. Bagian Obstetri dan Ginekologi FK Unand/RS Dr. M. Djamil Padang

Zilfira D. Adiponektin Pada Preeklampsia. Bagian Obstetri dan Ginekologi FK Unand/ RS Dr. M. Djamil Padang, 2012: 3

Ekhator CN, Ebomoyi MI. Blood Glucose and Serum Lipid Profiles During Pregnancy. African Journal of Diabetes Medicine, 2012; 20:16-19

Hubbel CA, Roberts JM. Metabolic Syndrome and Preeclampsia. In Chesley Hypertensive Disorders In Pregnancy 3rd Edition. Elsevier, 2009.

Drobny J. Clinical Study: Metabolic Syndrome and The Risk of Preeclampsia. Bratisl Lek Listy, 2009; 110(7): 401-403

Ray JG, Diamond P, Sinh G, Bell CM. Brief Overview of Maternal Tryglicerides As A Risk Factor For Preeclampsia. International Journal of Obstetric and Gynaecology RCOG, 2006.

Roberts JM, Gammil H. Insulin resistence in preeclampsia. Hypertension, 2006; 47: 341- 342

Masuyama H, et al. Severe Superimposed Preeclampsia with Obesity, Diabetes and a Mild Imbalance of Angiogenic Factors. Acta Med Okayama, 2012; 66(2) : 171-175

Seely EW, Solomon CG. Insulin Resistance and Its Potential Role In Pregnancy Induced Hypertension. The Journal of Endocrinology and Metabolism, 2003; 8(6): 2393-2398.

Thadhani R, Ecker JL, Mutter WP. Insulin Resistance and Alteration In Angiogenesis: Additive Insult That May Lead To Preeclampsia. Hypertension, 2004; 43: 988- 992.

Wolf M, Sandler L, Munoz K. First Trimester Insulin Resistance And Subsequent Preeclampsia. Journal of Clinical Endocrinology and Metabolism, 2002; 87(4): 1563-1568

Evruke C, et al. Comparison of lipid profile in normal and hypertensive women. Ann Saudi Med, 2004; 24(5): 382-385

Gohil JT, Patel PK, Priyanka G. Estimation of Lipid Profile in Subjects of Preeclampsia. The Journal of Obstetrics and Gynecology of India, 2011; 61(4): 399–403

Sahu S, et al. Study of Lipid Profile, Lipid Peroxidation and Vitamin E In Pregnancy Induced Hypertension. Indian J Physiol Pharmacol, 2009; 53(4): 365-369

Sharami SH, Tangestani AT, Faraji M. Role of Dyslipidemia In Preeclamptic Overweight

Pregnant Women. Iran J Reprod Med, 2012; 10(2): 105-112.

Brien O, Ray JG, Chan WS. Maternal Body Mass Index and The Risk Of Preeclampsia : A Systematic Overview. Epidemiology, 2003; 14(3): 368-374.

Castano IB, Sanchez PH, Perez NA. Maternal Obesity In Early Pregnancy and Risk of Adverse Outcomes. Open Access PLOS One, 2013; 8: 1-6.

Cnossen JS, Leeflang MM, Haan ED. Accuracy of Body Mass Index In Predicting Preeclampsia: Bivariate Metaanalysis. BJOG An International Journal ofObstetric and Gynaecology RCOG, 2007.

Yazdani S, Yosofniyapasha Y, Nasab BH, et al. Effect of Maternal Body Mass Index On Pregnancy Outcome and Newborn Weight. BMC Research Notes, 2012; 5: 34.

Anderson NH, McCowan LME, Fyfe EM. The Impact of Maternal Body Mass Index On The Phenotype of Preeclampsia

: A Prospective Cohort Study. BJOG An International Journal of Obstetrics and Gynaecology, 2012; 1-6.

Grobman WA, Kazer RR. Serum Insulin, Serum Insulin-Like Growth Factor –I, and Insulin Like Growth Factor Binding Protein -1 In Women Who develop Preeclampsia. PubMed Obstetric and Gynecology, 2001; 97(4): 521-6.

Salamalekis E, Vitoratos N, Makrakis E. No Association Between Insulin Resistance and Preeclampsia. Journal Fetal Neonatal Medicine, 2005; 18(2): 113-5.

Hauth JC, Clifton RG, Roberts JM. Maternal Insulin Resistance and Preeclampsia. American Journal of Obstetrics and Gynecology, 2011; 204: 327.

Sowers JR, Saleh A, Sokol RJ. Hyperinsulinemia and insulin resistance are associated with preeclampsia in african- americans. The American Journal of Hypertension, 1995; 8: 1-4.

Sinha H, Singh GP, Gupta K. Effect of Preeclampsia on Insulin Sensitivity. International Journal of Applied and Basic Medical Research, 2014; 4(1): 7-10.

Roberts RN, Henriksen JE, Hadden DR. Insulin Sensitivity In Preeclampsia. British Journal of Obstetrics and Gynaecology, 1998; 105: 1095-1100.

Anjum R, Zahra N, Rehman K, et al. Comparative Analysis of serum Lipid Profile Between Normotensive and Hypertensive Pakistani Pregnant Women. Journal of Molecular and Genetic Medicine, 2013; 7: 2

Kausar H, Dabhadkar S, Mehendale S, Kulkarni YS. Waist Circumference, BMI, Lipid Profile Between 6-16 Weeks of Pregnancy As Predictor of Gestasional Hypertension and Preeclampsia. Indian Journal of Applied Research, 3(2) :274-276

Kalar MU, Kalar N, Mansoor F. Preeclampsia and Lipid levels - A Case Control Study. International Journal of Collaborative Research in Internal Medicine and Public Health, 2012; 4(10): 1738-1745.

Williams MA, Enquobahrie, Butler CA. Relationship of Maternal Plasma Lipid Concentration In Early Pregnancy And Risk of Preeclampsia. American Journal of Hypertension, 2004; 17(7): 547-81.

Downloads

Published

2019-12-12

Issue

Vol. 3 No. 2 (2019)

Section

RESEARCH ARTICLE

License

Copyright (c) 2019 JOURNAL OBGIN EMAS

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright

Authors who publish with this journal agree to the following terms:

  1. Authors retain the copyright of published articles and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

License:

Andalas Obstetrics and Gynecology Journal (AOJ) is published under the terms of the Creative Commons Attribution 4.0 International License. This license permits anyone to copy and redistribute this material in any form or format, compose, modify, and make derivatives of this material for any purpose, including commercial purposes, as long as they credit the author for the original work.