Difference in Mean Maternal Activin A Serum Levels on Severe Preeclampsia and not Severe Preeclampsia

Authors

  • Dovy Djanas Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Bayu Pramudyo Ariwibowo Resident of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Hafni Bachtiar Public Health Department, Faculty of Medicine, Andalas University Padang

DOI:

https://doi.org/10.25077/aoj.1.1.30-37.2017

Abstract

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.

Keywords: Activin A, severe preeclampsia, not severe preeclampsia

References

Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap L, and Wenstrom KD.Williams Obstetrics (24th Edition ed.). The McGraw-Hill Companies. New York. 2014.

Zilfira D. Adiponektin pada Preeklamsia.Bagian Obstetri dan Ginekologi FK Unand/ RS Dr. M. Djamil Padang. Padang. 2012.

Lubis DN. Gambaran Kematian Ibu di Bagian Obstetri Ginekologi RSUP Dr. M. Djamil Padang Tahun 2011-2012. Bagian Obstetri dan Ginekologi FK UNAND. Padang. 2013.

Redman. Pregnancy-related hypertension. Dalam: Maternal-Fetal Medicine Principles and Practice. Edisi 5. Saunders. Philadelpia: 2012. 859-892.

Ling Yu, Li Dong, Liao Q P, high levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosus by promoting nodal signaling. J Clin Endocrinol Metab 2012. 97(8): E1370-E1379.

Silver HM, et al. Mechanism of increased maternal serum total activin A and inhibin A in preeclampsia. J Soc Gynecol Investig. 2008. 9: 308-12

Stefano L, Florio P, Reis FM, Petraglia F. Expression and secretion of activin A: possible physiological and clinical implication. Euro J Endocrinol. 2001. 225-36.

Muttukrishna S, Groome N, Redman, Sargent. Serum inhibin A and activin A are elevated prior to the onset of preeclampsia. Hum Reprod. 2006. 15:1640-5.

Davidson E, Riley S, Robert S, Shearing C, Groome N. Maternal serum activin, inhibin, human chorionic gonadotropin and α-fetoprotein as second trimester predictors of preeclampsia. BJOG. 2005. 110: 46-52.

Wallace E, Kolsky M, Edwards, Baker, Jenkin G. Maternal serum activin A levels in association with intrauterine fetal growth restriction. BJOG. 2009. 110:306-10.

Jeffrey A, Tailor R, Schellenberg JC. Serum activin A, inhibin A, and follistatin concentrations in preeclampsia or small for gestational age pregnancies. Elsevier. 2002. 99: 267-74.

Gallinelli, Gennazeni AD, Matteo ML,

Caruso A, Woodruff. Episodeic secretion of activin A in pregnant women. Euro J Endocrinol. 1996. 135:340-4.

Keelan JA, Tailor R, Schellenberg J, Groome N, Mitchel M, and North R. Serum Activin A, Inhibin A and Follistatin Concentrations in Preeclampsia or Small for Gestational Age Pregnancies. Am J Obstet Gynecol. 2007. 99: 267-74.

Downloads

Published

2019-11-28

Issue

Vol. 1 No. 1 (2017)

Section

RESEARCH ARTICLE

License

Copyright (c) 2017 JOURNAL OBGIN EMAS

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright

Authors who publish with this journal agree to the following terms:

  1. Authors retain the copyright of published articles and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

License:

Andalas Obstetrics and Gynecology Journal (AOJ) is published under the terms of the Creative Commons Attribution 4.0 International License. This license permits anyone to copy and redistribute this material in any form or format, compose, modify, and make derivatives of this material for any purpose, including commercial purposes, as long as they credit the author for the original work.