The Mean Difference of Hemostatic Factor in Severe Preeclampsia, Eklampsia and Normal Pregnancy

Authors

  • Yogi Syofyan Resident of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Joserizal Serudji Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Hafni Bachtiar Public Health Department, Faculty of Medicine, Andalas University Padang

DOI:

https://doi.org/10.25077/aoj.3.1.27-36.2019

Abstract

There will be multiple organs changes in preeclampsia and eclampsia. One of them is a change in hemostasis system which is platelet activation, extrinsic and intrinsic cascade reaction and increasing of fibrinolytic activation. This is a cross sectional study conducted at Obstetric and Gynecologic Departement of Medical Faculty of Andalas University/ M Djamil Central Hospital in Padang on July 2014 with the number of samples are 44 persons. Samples are divided into 3 groups: Severe preeclampsia, eclampsia, and normal pregnancy. Platelet, PT,APTT, and D-Dimer counting were conducted and statistic analyzed was done with Anova dan Post Hoc Bonferoni. The more severe pregnancy, the lower platelet count and PT, but the dif- ference is not statistically significant between three groups: severe preeclampsia, eclampsia, and normal pregnancy (p < 0,05). Mean of APTT and D-Dimer is statistically significant due to condition of pregnancy. Post Hoc Bonferroni analysis showed a significant difference of APTT mean in the eclampsia, severe pre-eclampsia, and normal pregnancy (p <0,05 ). D-Dimer Mean shows a significant difference between normal pregnancy, severe preeclampsia, and eclampsia (p <0,05).

Keywords: Pregnancy condition, severe preeclampsia, eclampsia, normal pregnancy, platelet, PT, APTT, and D-Dimer

Author Biography

Joserizal Serudji, Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang

Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Andalas Padang

References

AJOG Vol 179 No 5. Mosby Inc.November 1998.

Bakta, I Made. Hematologi Klinik Ringkas. Edisi 1. EGC. Jakarta. 2007.

Madi J, Sulin. D. Angka kematian Pasien preeklampsia dan Eklampsia RS Dr M Djamil padang tahun 1998-2002. Bagian Obstetri dan Ginekologi FK Unand/RS Dr. M. Djamil. Padang.

Baskett T. Disseminated Intravascular Coagulation (DIC) in Pregnancy. 2010.

Belammy L, Casas JP, Hingorani AD, Williams DJ. Preeclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335:974.

Chamberlain G, Benet P. Basic science in obstetric and gynaecology. Edinburgh: Churcll livingstone; 2002.

Cunningham, F.G et al. William Obstet- rics 23nd. Pregnancy Hypertension. The McGraw-Hill Companies, Inc. New York; 2010. 706-756

Dekker G, Robillard PY. The birth interval hypothesis-does it really indicate the end of praternity hypothesis? J Reprod Immunol 2003;59:245-51.

Duley L. Evidence and practice: the magnesium sulphate story. Clinical Obstetrics and Gynaecology. 2005;19(1):57- 74.

Dildy III GA, Preeclampsia and Hypertensive Disorders in Pregnancy, Obstetric & Gynecologic Emergencies Diagnosis and Management, The McGraw – Hill Co, 2004; 96-103.

Duckitt K, Harrington D. Risk factors for preeclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:549-50.

Einarsson JI, Sangi-Haghpeykar H, Gardner NO. Sperm exposure and development of preeclampsia. Am J Obstet Gynecol. 2003;188:1241-3.

Farmakologi dan terapi UI edisi 5. Jakarta. 2007.

Friemadman SA, Schiff E, Lubarsky SL, Sibai BM. Expectant management of severe preeclampsia remote from term. Clin Obstet Gynecol. 1999; 42: 470-8.

Granger JP, Pathophysiology Hypertension During Preeclampsia Linking Placenta Ischemia With Endothelial Disfunction.Copyrights ACOG. 2003. http://www.acog. org/ acm/pdf/36.pdf

Karsono B, Pertumbuhan Janin Terhambat, Makalah Lengkap Kursus Dasar Ultrasonografi & Kardiotokografi, RSUD Dr. Saiful Anwar. Malang. 2002.

Labelle CA, Kitchens CS. Disseminated intravascular coagulation: Treat the cause, not the lab values. Department of Medicine, University of Florida College of Medicine, Gainesville. Dalam: Cleveland Clinic Journa of Medicine Vol.72 No.5. Florida. 2005; 377-97.

Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002; 287:3183-6.

Levi M. Disseminated Intravascular Coagulation (DIC) in Pregnancy and the Peri-partum Period. Department of Internal Medicine, Academic Medical Center, University of Amsterdam. Dalam: Trombosis Research 123 Suppl.2. The Netherlands: 2009. 563-4.

Merviel, P et al. Pathophysiology of Preeclampsia: Links with Implantation Disorders. European Journal of Obstetrics & Gynecology Vol 115. Elsevier. 2004.

Mushambi MC, Halligan AW, Williamson K, Recent Developments of the Pathophysi- ology and Management of Pre – eclampsia. Br J Anaesth. 1996; 76 : 133–148.

Ngoc NT. Causes of stillbirths and early neonatal deaths: data from 7993 pregnancies in six developing countries. Bull World Health Organ. 2006; 84:699-705.

O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of preeclampsia: a systematic overview. Epidemiology. 2003; 14:368–74.

Orlikowski CEP, et al. Thrombelastography Change in Pre-eclampsia and Eclampsia. British Journal of Anaesthesia. 1996; 77:157-61.

Pridjian, G. Preeclampsia. Part 1: Clinical and Pathophysiologic Considerations. CME Vol 57 No 9. Lippincott Williams & Wilkins. 2002.

Ramsay JE, Stewart F, Green IA, Sattar N. Microvascular dysfunction: a link between preeclampsia and maternal coronary heart disease. BJOG. 2003; 110:1029-31.

RCOG. Management of severe pre- eclampsia/eclampsia. RCOG Guideline NO. 10(A). Royal College of Obstetricians and Gynaecologists. London. March 2006.

Rekam Medik RSUP M Djamil. Data angka kematian Preklampsia. Padang 2010.

Roberts JM. Pregnancy-related hypertension. In Maternal-Fetal Medicine Principles ansd Practice. 5th ed. Saunders. Philadelphia. 2004; p :859-892.

Roeshadi HR. Hipertensi dalam kehamilan. Dalam : Ilmu kedokteran fetomaternal. Ed pertama. Himpunan Kedokteran Fetomaternal Perkumpulan Obstetri dan Ginekologi Indonesia. Surabaya. 2004: 494- 500.

Saifuddin AB (ED). Nyeri Kepala, Gangguan Penglihatan, Kejang dan atau Koma, Tekanan Darah tinggi. Dalam : Buku Panduan Praktis Pelayanan Kesehatan Maternal dan Neonatal. Yayasan Bina Pustaka Sarwono Prawiroharjo. Jakarta. 2002; M31- M46.

Sibai BM. Magnesium Supfate Prophylaxis in Preeclampsia: Evidence From Randomized Trials Clinical Obstetrics and Gynecology. 2005;48 478-88.

Sibai, Baha M, and Dekker GA. Etiology and Pathogenesis of Preeclampsia: Current Concepts.

Skjaerven, R et al. The Interval Between Pregnancies and The Risk of Preeclampsia. NEJM Vol 346 No 1. Massachusetts Medical Society. 2004.

Stewart C. Disseminated Intravascular Coagulation (DIC). Australia Critical Care. 2001; 14(2): 71-75.

Sukrisman L. Koagulasi Intravaskular Diseminata. Dalam: Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi IV. Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia. Jakarta. 2010; 777-9.

Text book of medical physiology eleventh editions. Guyton, AC and Hall, JE. Elsivier. Pensylvania. 2006, Vol. 1.

VanWijk MJ, Kublickiene K, Boer K, VanBavel E. Vascular Function in Preeclampsia. Department of Obstetrics

and Gynecology, Academic Medical Center, Amsterdam. Dalam: Cardiovascular Research 47. Netherlands. 2000. 38-48.

Wang JX, Knottnerus AM, Schuit G, Norman RJ, Chan A, Dekker GA. Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia. Lancet. 2002; 359:673–4.

Wiknjosastro, H. Ilmu Kebidanan. Yayasan Bina Pustaka Sarwono Prawirohardjo. Jakarta. 2008.

Widjaja, AC. Uji Diagnostik Pemeriksaan Kadar D-Dimer Plasma Pada Diagnosis Stroke Iskemik. Bagian Patologi Klinik Fakultas Kedokteran Universitas Dipone- goro. Semarang. 2010.

Wolf M, Sandler L, Munoz K, Hsu K, Ecker JL, Thadhani R. First trimester insulin resistance and subsequent preeclampsia: a prospective study. J Clin Endocrinol Metab

World Health Organization (WHO). Dibalik angka - Pengkajian kematian maternal dan komplikasi untuk mendapatkan kehamilan yang lebih aman. WHO. Indonesia. 2007.

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Published

2019-01-10

Issue

Vol. 3 No. 1 (2019)

Section

RESEARCH ARTICLE

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