Diagnostic Value of Cyclooxygenase-2 Serum Levels in Predicting Preterm Labor

Authors

  • Wiwin Suhandri Resident of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Dovy Djanas Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang

DOI:

https://doi.org/10.25077/aoj.4.1.28-34.2020

Abstract

Objective: To determine the value of serum cyclooxygenase 2 in predicting preterm labor

Method: Examination of serum COX-2 levels by ELISA method in pregnant women with 28 weeks to 36 weeks of pregnancy compared with pregnant women with ≥37 weeks of gestation at the time of first stage of active phase

Results: It is known that the average COX-2 level in preterm labor is 21.88 ± 18.22 higher than in term labor which is 4.88 ± 2.35 ng / ml, the statistical test results obtained p = <0.001 serum Cyclooxygenase 2 at preterm deliveries and term deliveries. The value of serum cyclooxygenase 2 levels in predicting preterm labor is at a cut point of 7.0.0 ng / ml with a sensitivity of 86.1% and a specificity of 86.1%

Conclusion: There were significant differences in serum cyclooxygenase 2 levels in preterm labor and term delivery

Keywords: cyclooxygenase 2, memprediksi persalinan preterm, persalinan preterm.

References

Buhimschi CS, NormanJE, Creasy RK, Resnik R, Iams JD, Lockwood CJ, Moore TR, et al. In Creasy & Resnik’s Maternal-Fetal Medicine Principles and Practice. Elsevier. 2014: 599-623.

WHO. Preterm Birth. Fact Sheet. 2016.

Prawiroharjo, Sarwono. Ilmu Kebidanan. 4th ed. Jakarta: PT Bina Pustaka Sarwono Prawiroharjo; 2010: 667-676

Abadi A. Persalinan preterm, Ilmu Kedokteran Fetomaternal. Surabaya: Himpunan Kedokteran Fetomaternal POGI; 2004: 364-380.

Shenavai S, Preissing S, Hoffmann B, Dilly M, Pfarrer C, Ozalp G, et al., Investigations into the mechanisms controlling parturition in cattle: Soc Reprod Fertil. 2010; 144: 279-92.

Condon JC, Hardy DB, KovaricK, Mendelson CR.. Up-Regulation of the Progesterone Receptor (PR)-C Isoform in Laboring Myometrium by Activation of Nuclear Factor-kB May Contribute to the Onset of Labor through Inhibition of PR Function. Mol Endocrinol.2006; 20 (4): 764-75.

Jacques AL. Two different regimen of preinduction ripening of the uterine servix with prostaglandin E2: randomized clinical study. Eur J Obstet Gynecol Reprod Biol.1993; 50 (3): 163-8.

Sagol S. Role of apoptosis, bcl-2 and bax protein expression in premature rupture of fetal membrane. J Reprod Med.2002; 47 (10): 809-15.

Palliser HK, Hirst J, Ooi GT, Rice G, Dellios N, et al. Prostaglandin E dan F Receptor Expression and Myometrial Sensitivity at Labor Onset in the Sheep. Biol Reprod.2004; 72: 937-43.

Mogami H, Kishore AH, Shi H, Keller PW, Akgul Y, Word RA. Fetal Fibronectin Signaling Induces Matrix Metalloproteases and Cyclooxygenase-2 (COX-2) in Amnion Cells and Preterm Birth in Mice. J Biol Chem.2013; 288: 1953-66.

Reinebrant HE, Pileggi-Castro C, Romero CLT, Dos Santos RAN, Kumar S, Souza J, Flenady V. Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Systematic Review. 2015; 6

Equils O, Nambiar P, HobelCJ, Smith R, Simmons CF, Vali S. A Computer Simulation of Progesterone and Cox2 Inhibitor Treatment for Preterm Labor. PLoS ONE.2010; 5 (1): 8502.

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Published

2020-01-10

Issue

Vol 4, No 1 (2020)

Section

RESEARCH ARTICLE

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