The Effect of Giving Prophylactic Antibiotic Ceftriaxone and Cefazolin and Giving Ceftriaxone Before and After Surgery to The Risk of Postoperative Wound Infection in Postoperative Patients
DOI:
https://doi.org/10.25077/aoj.4.1.77-86.2020Abstract
Objective : To determine the effect of giving prophylactic antibiotic ceftriaxone and cefazolin and giving ceftriaxone before and after surgery to the risk of postoperative wound infection in postoperative patients.
Method: This study was an experimental study with a post test control group design that looked at the differences in the effect of administration of ceftriaxone, cefazolin, and ceftriaxone before and after surgery on the risk of postoperative wound infection. The population in this study were patients planned for surgery in the Obstetric and Gynelologic Departement of Dr. M. Djamil General Hopital, Padang. The number of samples used by 30 people with a group of 10 people each group. The study began in August until the number of samples was fulfilled. Univariate analysis was used to see the frequency, percentage, mean, and standard deviation. Bivariate analysis using Chi-square test with 95% CI (α <0.05) was used to see differences in the effect of the three antibiotic procedures.
Results: There were no cases of postoperative wound infection based on the three procedures used. There was no difference in the effect of prophylactic antibiotics in postoperative infections. Conclusion: There was no difference in the effect of the three procedures for prophylactic antibiotics in postoperative infections.
Keywords: Prophylactic Antibiotics, Surgical Wound Infections, Cefazolin, Ceftriaxone, Superficial incisional SSIReferences
WHO. Global guidelines for the prevention of surgical site infection. J Hosp Infect. 2017;95(2):135–6
Marni H, Djanas D. Pola Bakteri dan Sensitivitasnya Terhadap Antibiotik pada Pasien Rawat Inap Bagian Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang pada Bulan Mei 2017-Mei 2018. Universitas Andalas; 2018.
Center for Disease Control and Prevention. Procedure-associated Module SSI (Surgical Site Infection). 2019.
Van Schalkwyk J, Van Eyk N. Antibiotic Prophylaxis in Obstetric Procedures. J Obstet Gynaecol Canada. 2017;39(9):e293–9.
American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Prevention of Infection After Gynecologic Procedures. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 172–89.
American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Use of Prophylactic Antibiotics in Labor and Delivery. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 103–19.
Kusaba T. Safety and Efficacy of Cefazolin Sodium in the Management of Bacterial Infection and in Surgical Prophylaxis. Clin Med Ther. 2009;1607–15.
Marathias SGK, Kadas JKB. Cephalosporins in Surgical Prophylaxis. J Chemother. 2001;13(1):23–6.
Thelwall S, Harrington P, Sheridan E, Lamagni T. Impact of obesity on the risk of wound infection following surgery: Results from a nationwide prospective multicentre cohort study in England. Clin Microbiol Infect [Internet]. 2015;21(11):1008.e1-1008.e8. Available from: http://dx.doi.org/10.1016/j.cmi.2015.07.003
Agodi A, Quattrocchi A, Barchitta M, Adornetto V, Cocuzza A, Latino R, et al. Risk of surgical site infection in older patients in a cohort survey: Targets for quality improvement in antibiotic prophylaxis. Int Surg. 2015;100(3):473–9.
Aditya R. Faktor Risiko Infeksi Luka Operasi Bagian Obstetri dan Ginekologi RSUD Ulin Banjarmasin. J Berk Kesehat. 2018;4(1):10–7.
Assawapalanggool S, Kasatpibal N, Sirichotiyakul S, Arora R, Suntornlimsiri W, Apisarnthanara. The efficacy of ampicillin compared with ceftriaxone on preventing caesarean surgical site infection: an observational prospective cohort study. Antimicrob Resist Infect Control. 2018;22(7):1–8.
American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Prevention of Infection After Gynecologic Procedures. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 172–89.
Mehta D, Sharma AK. Cephalosporins: A Review on Imperative Class of Antibiotics. Inven Rapid Mol Pharmacol. 2015;2016(1):1–6.
Masoud MS, Ali AE, Nasr NM. Chemistry, classification, pharmacokinetics, clinical uses and analysis of beta lactam antibiotics : A review. J Chem Pharm Res. 2014;6(11):28–58.
Chiu C, Su L, Huang Y, Lai J, Chen H, Wu T, et al. Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan ᰔ. 2007;51(9):3404–6.
Muller A, Bertrand X, Talon D. Relationship between ceftriaxone use and resistance to third-generation cephalosporin among clinical strainsof E. cloacae. J Antimicrob Chemother. 2004;54(1):173–7.
Perkumpulan Obstetri Ginekologi Indonesia. Panduan Antibiotika Profilaksis Pada Pembedahan Obstetri dan Ginekologi. Jakarta; 2013.
Yulia R, Herawati F, Jaelani A, Anggraini W. Evaluasi penggunaan antibiotik dan profil kuman pada seksio sesarea di Rumah Sakit Umum Daerah Kabupaten Pasuruan. J Farm Klin Indones. 2018;7(2):69–77.
Hamidy MY, Fauzia D, Nugraha DP, Muttaqien MI. Penggunaan Antibiotik Profilaksis Bedah pada Sectio Cesarea di RSUD Arifin Achmad Provinsi Riau. JIK. 2016;10(1):33–7
Downloads
Published
Issue
Section
License
Copyright (c) 2020 JOURNAL OBGIN EMAS
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Authors who publish with this journal agree to the following terms:
- Authors retain the copyright of published articles and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
License:
Andalas Obstetrics and Gynecology Journal (AOJ) is published under the terms of the Creative Commons Attribution 4.0 International License. This license permits anyone to copy and redistribute this material in any form or format, compose, modify, and make derivatives of this material for any purpose, including commercial purposes, as long as they credit the author for the original work.