The correlation between Leptin Levels and Onset of Preeclampsia


  • Roza Sriyanti Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Johanes C. Mose Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Padjajaran University, Hasan Sadikin Hospital Bandung
  • Masrul Masrul Nutrition Department, Faculty of Medicine, Andalas University, Padang
  • Netti Suharti Microbiology Department, Faculty of Medicine, Andalas University, Padang



The purpose of this study is to find the correlation between leptin levels and the onset of preeclampsi. This study used a cross sectional comparative study design that conducted in May 2018 - April 2019 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Solok, RST Reksodiwiryo. We used consecutive sampling method which consists of 69 pregnant women who fulfill the inclusion and exclusion criteria. Leptin level tests were done using ELISA method. The average level of leptin in early-onset preeclampsia is found to be the highest when compared to the late-onset preeclampsia and normal pregnancy, 64.07 ± 78.27 vs. 30.46 ± 31.99 vs. 16.61 ± 24.49. This differentiation is highly significant with the ANOVA statistical test (p <0.05). There is a significant correlation between leptin levels with the onset of preeclampsia.

Keywords: preeclampsia early onset, preeclampsia late onset, leptin levels


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