Correlation of Colony Lactobacillus spp. with The Incident of Overactive Bladder with OBSS Score at Pauh Primary Health Center Padang

Authors

  • Rimbun Wahyu Gumilar Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Chatib Quzwain District Hospital Sarolangun
  • Bobby Indra Utama Sub Division of Urogynecology, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Hafni Bachtiar Public Health Department, Faculty of Medicine, Andalas University Padang

DOI:

https://doi.org/10.25077/aoj.5.1.56-62.2021

Abstract

Background : Overactive bladder (OAB) is a group of urgent symptoms, with or without urgent incontinence. Research shows that some Lactobacillus spp. can be a sign of a women bladder’s good health; and found a decrease number of Lactobacillus spp. in patients with OAB. This study aims to assess the correlation of Lactobacillus spp. colony with OAB using the OABSS score at Pauh Primary Health Center, Padang.

Method : This research is an analytic study with a cross sectional comparative design. The research was conducted from December 2019 to February 2020 at Pauh Primary Health Center. All women aged 20-40 years who came to Pauh Primary Health Center during the study period were included in the study. Pregnant women, having pelvic abnormalities and a history of other urinary tract diseases or having a history of hypertension and diabetes mellitus were excluded in the study. Numerical data are presented in the form of central tendency. Bivariate analysis was performed using the t-independent test if the data distribution was normal and the Kolmogorov-Smirnov test if the distribution of the data was not normally distributed.

Result: There were 42 samples consisting of 21 OAB respondents and 21 normal respondents. The age of the respondents in the OAB group was 28 ± 6.8 years, while the normal group was 32 ± 7.3 years (p> 0.05). The number of Lactobacillus spp colonies in the normal group was higher than the OAB group, namely 16,389,670 ± 74,380,427.9 CU / ml compared to 15,229,634 ± 67,553,932.9 CU / ml (p> 0.05).

Conclusion: There was no correlation between the number of Lactobacillus Spp colonies and the incidence of Overactive Bladder. It is necessary to do further research regarding other risk factors associated with the incidence of OAB and the causes of the decrease number of Lactobacillus spp colonies in OAB patients and the presence of other microorganisms, especially pathogenic microorganisms.

 

Keywords: overactive bladder, Lactobacillus, OABSS score

References

Junizaf. Book Teach Gynecology. 2003;7-10.

Stewart W, Van Rooyen JB, CundiffGW, et al. Prevalenceand burden of overactive bladder in the United States. Worldd J Urol. 2003; 20 (6): 327- 36.

Irwin DE, Milsom I, Hunskaar S, et al. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Result of the EPIC study. Eur Urol. 2006; 50: 1306-15pp.

Tirtayasa PMW, RahardjoHE. A survey on the management of overactive bladder by Indonesian urologists. Med J Indonesia. 2015; 24 (2): 91-6.

Pearce MM, Hilt EE, Rosenfeld AB, et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. MBio. 2014; 5: e01283–314.

Thomas-White K, Brady M, Wolfe AJ, et al. The bladder is not sterile: History and current discoveries on the urinary microbiome. CurrBladderDysfunct Rep. 2016; 11: 18–24.

Pearce MM, Zilliox MJ, Rosenfeld AB, et al. The female urinary microbiome in urgency urinary incontinence. Am J Obstet Gynecol. 2015; 213: 347.e1–347.e11

Khasriya R, Sathiananthamoorthy S, Ismail S, et al. Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lowerurinary tract symptoms. J Clin Microbio. 2013; 51: 2054–62.

Karstens L, Asquith M, Davin S, et al. Does the urinary microbiomeplay a rolein urgency urinary incontinence and its severity? rontCell Infect Microbiol.2016; 6: 78.

Nelson DE, Dong Q, Van Der Pol B, et al. Bacterial Communities of the coronal sulcus and distal urethra of adolescent males. PLoS One. 2012; 7: e36298.

Ayres J. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. Cell. 2016; 165: 1323–31.

Le PT, Pearce MM, Zhang S, Campbell EM, ok CS, Mueller ER, Brincat CA, Wolfe AJ, Brubaker L. IL22 regulates human urothelial cell sensory and innate functions through modulation of the acetylcholine response, immunoregulatory cytokines and antimicrobial peptides: an assessment of an in vitro model. PLoSOne. 2014; 9: e111375.

Downloads

Published

2021-01-18

Issue

Section

RESEARCH ARTICLE