The Effect of Oral Albumin Intake on Serum Albumin Levels in Preeclamsia Patients With Hypoalbuminemia in RSUP Dr. M. Djamil Padang
DOI:
https://doi.org/10.25077/aoj.5.1.69-81.2021Abstract
Introduction : Albumin main function is maintaining the plasma colloid oncotic pressure. Preeclampsia cause a decrease in serum albumin in the pregnant woman. Low albumin levels increase mortality, longer wound healing and longer hospital stays. The intake of oral albumin is expected to be effective in increasing the level of albumin in the blood.
Objective : To determine the effect of freeze dryer method intake compared to liquid snakehead fish extract in patients with preeclampsia and hypoalbuminemia.
Material and methods : Using pre and post-test control group design.The total sample was 38 patients with severe preeclampsia with hypoalbuminemia, divided into control and intervention groups. Control was given the intake of liquid snakehead fish extract, in the intervention was given the Freeze dryer method. The research data were analyzed using the Mann Whitney test method and the Wilcoxon test.
Results : In the intervention group the mean pretest albumin level was 2.66 ± 0.17 gr / dl and on the 4th day it was 3.13 ± 0.16 gr / dl (p = 0.000). In the control group the mean pretest albumin level was 2.72 ± 0.15 gr / dl and on the 4th day it became 3.06 ± 0.14 gr / dl (p = 0.000). On the 4th day after treatment, the increase in serum albumin levels in the intervention group was 0.47 ± 0.19 gr / dl; whereas in the control group was 0.34 ± 0.10 gr / dl with a value of p = 0.031 (p <0.05).
Conclusion : The freeze dryer method (freeze dryer method ) for the Cork Fish Extract resulted in a higher increase in albumin levels than the liquid snakehead fish extract.
Keywords: Preeclampsia, Hypoalbuminemia, freeze dryer method of Snakehead Fish ExtractReferences
Cunningham L, Bloom, Dashe. Hypertensive Disorders. Williams Obstetric 25 ed. New York: Mc Graw Hill; 2017. p. 1086-8
Frederic, T, Allo, et all. Pengaruh asupan albumin oral (vipalbumin) terhadap kadar albumin serum pada penderita hipoalbuminemia berat pasca laparotomi emergensi di rumah sakit Wahidin Sudirohusodo Makassar. Mei, 2012.
Sugio, S, Kashima.A, dkk. Crystal Structure of human serum albumin at 2.5 A Resolution. Artikel pada : Protein Engineering vol.12. no.6 pp.439-446. Osaka, Jepang.1999
Nicholson, JP, Wolmarans, MR, Park, GR. The Role Of Albumin In Critical Illness in Review Article. Br J Anaesth.85 (4). 2000. Pp 599-610
Lintang, LS. Gambaran Fraksi Protein Darah Pada Preeklampsia Dan Hamil Normotensif. Tesis Program Magister Kedokteran Klinik-Spesialis Ilmu Obstetri dan Ginekologi. FK USU. Medan. (Unpublished). 2003
Saringat Baie et al : Amino Acid Composition Of Snakehead Fish ( Channa Striatus) of Various Sizes Obtained at Different Times of The Year, Malaysian Journal of Pharmaceutical Sciences, Volume 3, Nomor 2, 2005, 19 – 30, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia. 2005
Chairuddin, B. 2012. Efektivitas Pemberian Kapsul Albumin Ekstrak Ikan Gabus Terhadap Kenaikan Kadar Albumin dalam Darah Pasien Preeklampsia Berat Pasca Seksio Sesarea. Tesis ilmu biomedik , FK UNS. Solo. (unpublished). 2012
Hidayanti, H. 2006. Pengaruh Pemberian Kapsul Kosentrat Ikan Gabus pada Pasien Bedah Di RS. Dr. Wahidin Sudirohusodo. Tesis. Program Pascasarjana. (Unpublished).
Ulrich Kragh-Hansen, Human Serum Albumin: A Multifunctional Protein, dalam : Albumin in medicine, Pathological and Clinical Applications, Singapore, Springer Science+Business Media, 2016, hal : 1-30
Burl R. Don, Kaysent.G, Serum Albumin : Relationship to Inflammation and Nutrition, Seminars in Dialysis, Vol 17, No 6 (November–December), pp. 432–437, 2004
Caraceni.P, dkk. Clinical indications for the albumin use: Still a controversial issue. Review article: European Journal of Internal Medicine.Bologna. Italia, 2003
Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. Pregnancy hypertension. 2018;13:291-310
Butalia S, Audibert F, Cote AM, Firoz T, Logan AG, Magee LA, et al. Hypertension Canada's 2018 Guidelines for the Management of Hypertension in Pregnancy. The Canadian journal of cardiology. 2018;34(5):526-31
Carol Lai M, Stephanie A. Coulter M, Amy Woodruff M. Hypertension and Pregnancy. Texas Heart Institute Journal. 2017;44:350-8
Catov JM, Nohr EA, Bodnar LM, Knudson VK, Olsen SF, Olsen J. Association of periconceptional multivitamin use with reduced risk of preeklampsia among normal-weight women in the Danish national birth cohort. Am J Epidemiol. 2009;169(11):1304–1311.
Chahine KM, Sibai BM. Chronic Hypertension in Pregnancy: New Concepts for Classification and Management. American journal of perinatology. 2018.
Kine Marita Knudsen Sand Malin Bern, Jeannette Nilsen, HannaTheodora Noordzij, Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics. Frontiers in Immunology , Volume 5, Article 682. 2015
Anraku M, Chuang VTG, Maruyama T, Otagiri M, Redox properties of serum albumin. Biochim Biophys Acta 1830:5465–5472. 2013
Silbernagl Stefan, Lang Florian , Kidney Disease in Pregnancy pada Color Atlas of Pathophysiology. Thieme, Stuttgart-Newyork. Hal : 116. 2000.
Shapiro M Janet, MD. Critical care of the obstetric patient. J Intensive care Med. 2006; 21: 278-286.
Ghanawati-mina abbossi, et al. Review Article Pregnancy and Laboratory studies. A Reference table for clinician. American College of Obsetry and Gynecology. 2009. vol 114, no. 6.
Larsson A, et al. Reference value for Clinical Chemistry test during normal pregnancy. BJOG an International journal of Obstetry and gynecology. 2008. 115; 874-881.
Anraku M, Shintomo R, Taguchi K, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M. Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants. Life Sci 134:36–41, (2015)
Higby K, Suiter C, Phelps J, et al. Normal values of urinary albumin and total protein excretion during pregnancy. Am J Obstet Gynecol 1994;171(4):984–9.
Hill C Cristina, MD. Physiologic Changes in Pregnancy. Surgical Clinics of North America. Surg Clin N Am 88 (2008) 391–401.
Rahajuningsih Dharma, Noroyono Wibowo, Hessyani P.T. Raranta. Disfungsi Endotel Pada Preeklampsia. Makalah Kesehatan, Vol. 9, No. 2, Desember 2005: 63-69
Bienk K, Dagnæs-Hansen F, Wengel J, Kragh-Hansen U, Howard KA. Albumin-mediated protection, reduced immunogenicity and extended circulatory half-life of cholesterol modifi ed small interfering RNA. Presented at the 2015 Annual Meeting of Controlled Release Society, Edinburgh, Scotland, 2015. July 26–29. Abstract 844.
Chen Z, He Y, Shi B, Yang D, Human serum albumin from recombinant DNA technology: challenges and strategies. Biochim Biophys Acta.2013. 1830:5515–5525.
Sastroasmoro, S. 2011. Dasar-Dasar Metodologi Penelitian Klinis. Jakarta : Sagung Seto
Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W, Structural and immunologic characterization of bovine, horse, and rabbit serum albumins. Mol Immunol. 2016. 52:174–182.
Mendez CM, McClain CJ, Marsano LS, Albumin therapy in clinical practice. Nutr Clin Pract 20:314–320 Merlot AM, Kalinowski DS, Richardson DR (2014) Unraveling the mysteries of serum albumin–more than just a serum protein. Front Physiol.2005.5:299, Article 299.
Arnedo,A., Irache,JM., Merodio,M., Espuelas, M.S. 2004.Albumin Nanoparticles Improved the Stability, Nuclear Accumulation and Anticytomegaloviral Activity of a Phosphodiesteroligonucleotide, 94 (1): 217-227.
Minomo A, Ishima Y, Chuang VTG, Suwa Y, Kragh-Hansen U, Narisoko T, Morioka H, Maruyama T, Otagiri M, Albumin domain II mutant with high bilirubin binding affinity has a great potential as serum bilirubin excretion enhancer for hyperbilirubinemia treatment. Biochim Biophys Acta.2013.1830:2917–2923.
Preston W George, Plusquin M, et all, Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations, , Chem. Res. Toxicol.2017.30, 2120−2129, Leuven, Belgium.
Mohanraj, V., dan Chen, Y. 2006. Nanoparticles-A Review, Pharmacology Research, 5 (1): 561-573.
Vikram Sindgikar, et all. Effect of serum albumin in wound healing and its related complications in surgical patients. US National Library of Medicine enlisted journal. Al Ameen J Med Sc i 2017; 10(2) : 132-135. Al Ameen Charitable Fund Trust, Bangalore.
Ana Cristina de Oliveira Gonzalez, et all. Wound healing - A literature review. An Bras Dermatol. Work conducted at the Gonçalo Moniz Research Center – Fundação Oswaldo Cruz (CPqGM/Fiocruz), Salvador, BA, Brazil. 2016;91(5):614-20.
Hirotaka Sugino, et all. Relation between the serum albumin level and nutrition supply in patients with pressure ulcer : retrospective study in an acute care setting. The Journal of medical investigation. Tokusihima, Japan. 2014. Vol. 61.
Hasan, Irsan, Anggraini T., 2008. Peran Albumin dalam Penatalaksanaan Sirois Hati. Divisi Hepatologi, Departemen Ilmu Penyakit Dalam FKUI/RSCM –Jakarta.
Susetyowati. 2007. Penatalaksanaan Gizi pada Pasien Bedah Digesif. ASDI Semarang: Pertemuan Ilmiah Nasional III.
Gupta,R. dan Kompella, UB., 2006.Nanoparticle Technology for Drug Delivery, Drug and The Pharmaceutical Sciences:159.
Nugroho Yudistiro Alit. 2016. Perbandingan Efektivitas terapi Albumin Ekstrak Ikan Gabus Murni dibanding Human Albumin 20% terhadap Kadar Albumin dan pH Darah Pada Pasien Hipoalbuminemia. Tesis Program Studi Ilmu Biomedik (Anastesi), Pascasarjana UNS, Surakarta.
Nilesh, J., Ruchi, J., Navneet, T., Brham Prakash, G., Deepak Kumar, J. 2010, Nanotechnology: A Safe and Effective Drug Delivery System, Asian Journal of Pharmaceutical and Clinical Research, 3(3):159-165.
Lockman, P.R., Mumper, R.J., Khan, M.A., Allen, D.D. 2002.Nanoparticle Technology for Drug Delivery Across The Blood-brain Barrier, Drug Dev Ind Pharm 28 (1): 1-13
Davda, J., Labhasetwar, V. 2002. Characterization on Nanoparticle Uptake by Endothelial Cells,Int J Pharm 233 (1-2):51-59.
Simon S, Abustam E, Said MI., 2014. Karakteristik Fungsional Tepung Putih Telur yang Dikeringkan Dengan Freeze Dryer Pada Suhu Dan Ketebalan Berbeda. Skripsi. Fakultas Peternakan. Universitas Hasanudin. Makassar.
Gerald Adams. 2007. The Principles of Freeze-Drying. In: Cryopreservation and Freeze-Drying, 2nd edition. New Jersey.: 15-38.
Yuniarti DW, Sulistiyati TD, Suprayitno E.,2013. Pengaruh Suhu Pengeringan Vakum Terhadap Kualitas Serbuk Albumin Ikan Gabus (Ophiocephalus striatus). THPi Student Journal, Vol 1, 1:1-9
Wang, Y., Stavem, K., Dahl, FA., Humerfelt, S., Haugen, T., 2008. Factors Associated with A Prolonged Length of Stay After Acute Exacerbation of Chronic Pulmonary Disease. Int J Chron Obstruct Pulmon Dis, 9; 99-105
Delgado, M., Rodriques, Medina, M., Gomez, A., Martinez, G., Mariscal, M., 2002. Cholesterol and Serum Albumin Levels as Predictors of Cross Infection, Death, and Length of Hospital stay, Jama Surgery, 137 (7) ; 805-812
Kurniawati, D. 2014. Perbandingan Terapi Albumin Teknologi Nano Dengan Kapsul Albumin Terhadap Peningkatan Kadar Albumin Dan Lama Perawatan. Departemen Anestesiologi Dan Terapi Intensif FK UNS/RSDM–Surakarta. http://dglib.uns.ac.id/dokumen/detail/41262/ALBUMIN-TERHADAP-PENINGKATAN-KADAR-ALBUMIN-DAN-LAMA-PERAWATAN
Al Ghazali Basima, et all. 2014. Study of the clinical significance of serum albumin level in preeklampsia and in the detection of its severity. American Journal of BioMedicine. 2(8): 964-974
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Andalas Obstetrics And Gynecology Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Authors who publish with this journal agree to the following terms:
- Authors retain the copyright of published articles and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
License:
Andalas Obstetrics and Gynecology Journal (AOJ) is published under the terms of the Creative Commons Attribution 4.0 International License. This license permits anyone to copy and redistribute this material in any form or format, compose, modify, and make derivatives of this material for any purpose, including commercial purposes, as long as they credit the author for the original work.
