The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia

Authors

  • David Perdana Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Ibnu Sina Simpang Empat Hospital West Pasaman
  • Defrin Defrin Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
  • Firdawati Firdawati Public Health Department, Faculty of Medicine, Andalas University Padang

DOI:

https://doi.org/10.25077/aoj.5.1.82-89.2021

Abstract

The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia

Keywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α

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Published

2021-01-18

Issue

Vol. 5 No. 1 (2021)

Section

RESEARCH ARTICLE

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