The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia

David Perdana, Defrin Defrin, Firdawati Firdawati

Abstract


The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia

Keywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α

Full Text:

PDF

References


Cunningham L, Bloom, Dashe. Hypertensive Disorders. Williams Obstetric 24 ed. New York: Mc Graw Hill; 2018. p.1086-8

ACOG. Hypertension in pregnancy. Washington : the American College of Obstetricans and Gynecologists; 2013.p. 22

Saito S. Preeclampsia, Basic, Genomic, and Clinical. Springer. 2018

Adhi Pribadi. Preeklampsia “Stoppable”. Sagung Seto. 2019

Sibai BM. Hypertension. In: Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, et al, editors. Obstetrics normal and problem pregnancies. 7th ed. Philadelphia: Elsevier; 2017. p. 661-705.

Raymond D, Peterson E. A Critical Review of Early-Onset and Late-Onset Preeclampsia. Obstetrical and Gynecological Survey by Lippincott Williams & Wilkins. 2011. Volume 66, Number 8.

Sriyanti R, Mose JC, Masrul, N. S. The difference in maternal serum Hypoxia-Inducible Factors-1a levels between early onset and late onset preeclampsia. Journal of Medical Science. 2019;7(13):2133-7.

Rath G, Aggarwa , Jawanjal P, Tripathi R, Batra A. HIF-1 Alpha and Placental Growth Factor in Pregnancies Complicated With Preeclampsia: A Qualitative and Quantitative Analysis. J of Clin Lab Anal. 2016; 30(75-83).

Wantania J, Bakri S, Pandelaki K, Chalid M. (2013). Altered level of Soluble fms-like Tyrosine Kinase 1 (sFlt1) and Hypoxia Inducible Factor-1α in Normotensive Pregnancy and Preeclampsia. Indones Biomed J 2013; 5(2):121-8.

Iriyama T, Wang , Parchim N, Song , Blackwell SC, Sibai B, et al. Hypoxia-Independent Upregulation of Placental Hypoxia Inducible Factor-1α Gene Expression Contributes to the Pathogenesis of Preeclampsia. Hyper AHA J. 2015 April.

Tal R. The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis. Bio of Rep. 2012; 87(6).

Davutoglu EA, Firat AA, Ozel A, Yilmaz N, Uzun I, Yuksel IT, et al. Evaluation of maternal serum hypoxia inducible factor-1a, progranulin and syndecan-1 levels in pregnancies with early and late onset preeclampsia. The Journal of Maternal Fetal & Neonatal. 2017;2017:1-7.

Akhilesh M, Mahalingam V, Nalliah S, Ali RM, Ganesalingam , Haleagrahara N. Participation of hypoxia-inducible factor-1a in the pathogenesis of preeclampsia-related placental ischemia and its potential as a marker for preeclampsia. Biomarker and Genom Med. 2014 June; 6(121-125).

Bobek G, Surmon L, Mirabito KM, et al. Placental regulation of ınflammation and hypoxia after TNF-a ınfusion in mice. Am J Reprod Immunol. 2015;74: 407–418.

Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin.Invest 2000; 105(5):577–587.

Galbiati S, Inversetti A, Causarano V, Stenirri S, Soriani N. HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia: a longitudinal prospective study in high risk population. Clin Chem Lab Med. 2015; 53(9).

Vermaa S, Pillay P, Naickerb T, Moodley J, Mackraj I. Placental hypoxia inducible factor -1a & CHOP immuno-histochemical expression relative to maternal circulatory syncytiotrophoblast micro-vesicles in preeclamptic and normotensive pregnancies. Euro J of Obs & Gyn Rep Bio. 2018; 220(18-24).

Liu W, Wang SJ, Lin QD. Study on the Expressions of PHD and HIF in Placentas from Normal Pregnant Women and Patients with Preeclampsia. Int. J. Biol. Sci.. 2014; 10

Rolfo A, Many A, Racano A, Tal R, Tagliaferro A, et al. Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies. PLoS ONE 2010; 5(10): e13288.

Galbiati S, Inversetti A, Causarano V, Stenirri S, Soriani N, Ambrosi A. HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia: a longitudinal prospective study in high risk population Clin Chem Lab Med. 2015;53(9):1339-47.




DOI: https://doi.org/10.25077/aoj.5.1.82-89.2021

Refbacks

  • There are currently no refbacks.