Ovarian Clear Cell Carcinoma which Detected in Ascitic Fluid Smear
DOI:
https://doi.org/10.25077/aoj.5.2.269-277.2021Abstract
Objective: To report the case of ovarian clear cell carcinoma with involvement of both ovaries and metastatic to ascitic fluid and the label mass in the bladder
Method: Case ReportÂ
Case: A 51 years old female presented with enlarging abdominal with gradual pain. The result of transabdominal sonography were multiple cysts with solid mass, suspected solid cystic ovarian neoplasm and ascites. The patient prepared for laparotomy; optimal debulking surgery, mass resection from bladder. Cytology examination was performed from ascitic fluid and it was confirmed by histopathology examination.
Result: Microscopic features on cytology examination of ascitic fluid smear was suggest carcinoma. Histological examination was confirmed the diagnosis and the result was ovarian clear cell carcinoma.
Discussion: Ovarian clear cell carcinoma is a rare subtype of epithelial ovarian cancer and comprises about 5-10% of ovarian carcinomas. Clear cell carcinoma tends to occur in the fifth to seventh decades. Cytology examination showed the cellular smear consists of groups of epithelial cells with large nucleus, hyperchromatic, pale-staining, vacuolated cytoplasm. There is also eosinophilic, extracellular substance. The presence of a tumor in ascitic fluid and the label mass in the bladder can categorize become IIB. This determined based on the FIGO’s ovarian tumor staging system.
Keywords: ovarian clear cell carcinoma; ascitic fluid.
References
Damiani D, Suciu V, Genestie C, Vielh P. Cytomorphology of ovarian clear cell carcinomas in peritoneal effusions. Cytopathology. 2016 Dec;27(6):427–32. PMID 26932246 [PubMed]
Joo HL, Shin YR, Rha SE, Park CS, Shim DJ, Kim K. Preoperative discrimination of tumour stage in clear cell carcinoma of the ovary using computed tomography and magnetic resonance imaging. Eur J Radiol. 2018;109:19–26. PMID 30527303 [PubMed]
Moriya T, editor. Pathology of female cancers: precursor and early-stage breast, ovarian and uterine carcinomas. Singapore: Springer Singapore; 2018. 211 p.
Nucci MR, Oliva E, editors. Gynecologic pathology. Edinburgh: Churchill Livingstone; 2009. 710 p.
Vrdoljak-MozetiÄ D, Stanković T, KraÅ¡ević M, VerÅ¡a-Ostojić D, Å temberger-Papić S, RupÄić S. Intraoperative cytology of clear cell carcinoma of the ovary. Cytopathology. 2006;17(6):390–5. PMID 17168923 [PubMed]
Crum CP, Laury AR, Hirsch MS. Gynecologic and obstetric pathology: high-yield patology. Philadelphia: Elsevier; 2016. 821 p.
Mutter GL, Prat J, editors. Pathology of the female reproductive tract. 3., rev. ed. London: Churchill Livingstone; 2014. 873 p.
Bibbo M, Wilbur DC. Comprehensive cytopathology. London etc.: Elsevier Health Stock; 2015. 1074 p.
Tang H, Liu Y, Wang X, Guan L, Chen W, Jiang H, et al. Clear cell carcinoma of the ovary: Clinicopathologic features and outcomes in a Chinese cohort. Medicine. 2018;97(21):e10881. PMID 29794794 [PubMed]
Martin ML, Halling K, Eek D, Reaney M. “Lower abdominal pains, as if I was being squeezed…in a clampâ€: a qualitative analysis of symptoms, patient-perceived side effects and impacts of ovarian cancer. Patient. 2020;13(2):189–200. PMID 31691205 [PubMed]
Kipps E, Tan DSP, Kaye SB. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research. Nat Rev Cancer. 2013;13(4):273–82. PMID 23426401 [PubMed]
WHO classification of tumours editorial board, editors. WHO classification of Tumours: Female genital tumours. 5th Ed. 2020. 631 p.
Goldblum JR, Lamps LW, McKenney JK, Myers JL, Ackerman LV, Rosai J, editors. Rosai and Ackerman’s surgical pathology. Eleventh edition. Philadelphia, PA: Elsevier; 2018. 1025–1040 p.
Kurman RJ, Hedrick Ellenson L, Ronnett BM, editors. Blaustein’s pathology of the female genital tract. Cham: Springer International Publishing; 2019. 1472 p.
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