The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center

Try Genta Utama(1*), Dovy Djanas(2)

(1) Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(2) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(*) Corresponding Author



Preeclampsia is a hypertensive disorder in pregnancy that occurs in 5-10% of pregnancies and occurs after 20 weeks of gestation and recovers spontaneously after delivery. Several studies have stated that one of the risks of hypertension in pregnancy is related to magnesium homeostasis. Magnesium plays an important role in forming new tissues (maternal and fetal). Pregnant women need a higher intake of magnesium than non-pregnant women of the same age. Magnesium deficiency during pregnancy not only causes problems for the nutrition of pregnant women and fetuses, but also associated with the occurrence of preeclampsia, preterm labor and muscle cramps during pregnancy. This study aims to determine the relationship between the average increase in blood magnesium levels with the incidence of preeclampsia in hypomagnesemic pregnant women.Keywords: preeclampsia, hypertension, blood magnesium levels

Full Text:



ACOG. Hypertension in pregnancy. Washington: the American College of Obstetricans and Gynecologists; 2013 .p. 22.

Cunningham L, Bloom, Dashe. Hypertensive Disorders. Williams Obstetric 24 ed. New York: Mc Graw Hill; 2014. p. 1086-8

Prawirohardjo S. Ilmu Kebidanan Edisi 4 Cetakan ke-2. Editor Wiknjosastro, dkk. Jakarta: PT Bina Pustaka Sarwono; 2009. Hal. 282-287, 290-294.

Arun J. Epidemiology of preeclampsia: Impact of obesity. Department of Obstetrics, Gynecology and Reproductive Sciences; 2013.

Birawa AD, Handisaputro H, Hadijono S. Kadar d-dimer pada ibu dengan preeklamsia berat dan normotensi di rsup dr. kariadi. Majalah Obstetri Ginekologi Indonesia; 2009. 33(2): 65-78

Dinas Kesehatan Kota Padang. Profil Kesehatan Kota Padang tahun 2014. Padang; 2015.

Anggaraini DG, Tamela P, Fitrayeni. Faktor Risiko Kejadian Preeklamsia pada Ibu Hamil di RSUP DR. M. Djamil Padang tahun 2014. Jurnal Kesehatan Masyarakat Andalas; 2015

Sibai BM. Hypertension. In: Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ERM, et al, editors. Obstetrics normal and problem pregnancies. 7th ed. Philadelphia: Elsevier; 2017. p. 661-705

Kanasaki Keizo, Kalluri Raghu. The biology of preeclampsia. International Society of Nephrology. NIH Public Access; 2009

Shaikh K. Das MD, Baloch GH, et al. Magnesium Associated Complications in Pregnant Women. World Applied Sciences Journal 17 (9); 2012. p.1074-1078

Raghupathy R. Cytokines as Key Players in the Pathophysiology of Preeclampsia. Journal Medical Principles and Practice; 2013. 22 (23), 8–19

Bullarbo M, Mattson H, Broman AK, Odman N and Nielsen TF. Clinical study magnesium suplementation and blood pressure in pregnancy a double blind randomized multicenter study. Journal of Pregnancy; 2018. 1-10.

Chaiworapongsa T, Chaemsaithong P, Yeo L, et al. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat Rev Nephrol; 2014. 10:466–480.2.

Kanasaki, Keizo. Kanasaki, Megumi. Angiogenic Defects in Preeclampsia: What is Known, and How Are Such Defects Relevant to Preeclampsia Pathogenesis?. Department of Diabetology and Endocrinology Kanazawa Medical University; 2013

Petersen, Susanne Schrey. Stepan, Holger. Anti-angiogenesis and Preeclampsia in 2016. Springer Science+Business Media. New York; 2017

Helmo, Fernanda Rodrigues. Angiogenic and antiangiogenic factors in preeclampsia. Pathology - Research and Practice. Elsevier; 2018

Iriyama, Takayuki. Wang, Wei. et al. Hyypoxia- Independent Upregulation of Placental Hypoxia Inducible Factor-1α Gene Expression Contributes to the Pathogenesis of Preeclampsia. Diunduh dari:; 2018

Tal, Reshef. The Role of Hypoxia and Hypoxia-Inducible Factor-1 Alpha in Preeclampsia Pathogenesis. Department of Obstetrics and Gynecology, Maimonides Medical Center. New York; 2012

Butalia S, Audibert F, Cote AM, Firoz T, Logan AG, Magee LA, et al. Hypertension Canada's 2018 Guidelines for the Management of Hypertension in Pregnancy. The Canadian journal of cardiology; 2018. 34(5):526-31.

Magee LA, von Dadelszen P. State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy. Mayo Clinic proceedings; 2018. 93(11):1664-77.


  • There are currently no refbacks.

Address for Correspondence:

Editorial Room Andalas Obstetrics and Gynecology Journal 3rd floor of KSM Obstetrics and Gynecology
RSUP Dr. M. Djamil Padang, Jl. Perintis Kemerdekaan Padang, Sumatara Barat, 25127