The Role Of Vitamin D And Calcium In Pre-Eclampsia And The Association With Neonatal Outcomes
(1) Obstetrics and Gynecology Departement, Medical Faculty of M Djamil general Hospital-Andalas University, Padang, West Sumatera, Indonesia
(2) Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
(3) Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
(*) Corresponding Author
DOI: https://doi.org/10.25077/aoj.7.1.253-266.2023
Abstract
Introduction: Pre-eclampsia is one of the main causes of maternal and neonatal death in developing
countries. A low vitamin D level can increase the risk of neonatal abnormalities. Clinical studies
reported various complications of low vitamin D levels, such as pre-eclampsia, gestational diabetes,
low birthweight, and caesarean section. This study aimed to investigate the role of vitamin D in
pregnancy with pre-eclampsia and its association with neonatal outcomes.
Methods: This is an observational analytical study uses a cross-sectional approach to investigate
vitamin D levels and pre-eclampsia, conducted in General Hospital Dr. M. Djamil Padang from Mei
2021 – April 2022. A total of 5 mL blood was withdrawn to analyzed vitamin D. This study has been
approved by Health Research Ethics Committee Andalas University (Approved number:
339/KEPK/2021).
Results: There was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between normal
pregnancy and pre-eclampsia patients (99,18 vs 72,53 pg/ml; p = 0,033). In the pre-eclampsia patients’
first APGAR score, there was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between
normal, moderate, and severe asphyxia groups (114,19 vs 66,75 vs 74,78 pg/ml; p = 0,025).
Conclusion: Measuring early maternal 1,25 dihydroxy vitamin D3 can lower the pre-eclampsia risks
and the impact the perinatal outcomes, particularly in determining first Apgar scores.
Keywords
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