The Role Of Vitamin D And Calcium In Pre-Eclampsia And The Association With Neonatal Outcomes

Authors

  • Tara Fadila Obstetrics and Gynecology Departement, Medical Faculty of M Djamil general Hospital-Andalas University, Padang, West Sumatera, Indonesia
  • Yusrawati Yusrawati Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
  • Hudila Rifa Karmia Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia

DOI:

https://doi.org/10.25077/aoj.7.1.253-266.2023

Keywords:

1, 25 dihydroxy vitamin D3, Calcium, Pre-eclampsia, Neonatal

Abstract

Introduction: Pre-eclampsia is one of the main causes of maternal and neonatal death in developing
countries. A low vitamin D level can increase the risk of neonatal abnormalities. Clinical studies
reported various complications of low vitamin D levels, such as pre-eclampsia, gestational diabetes,
low birthweight, and caesarean section. This study aimed to investigate the role of vitamin D in
pregnancy with pre-eclampsia and its association with neonatal outcomes.
Methods: This is an observational analytical study uses a cross-sectional approach to investigate
vitamin D levels and pre-eclampsia, conducted in General Hospital Dr. M. Djamil Padang from Mei
2021 – April 2022. A total of 5 mL blood was withdrawn to analyzed vitamin D. This study has been
approved by Health Research Ethics Committee Andalas University (Approved number:
339/KEPK/2021).
Results: There was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between normal
pregnancy and pre-eclampsia patients (99,18 vs 72,53 pg/ml; p = 0,033). In the pre-eclampsia patients’
first APGAR score, there was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between
normal, moderate, and severe asphyxia groups (114,19 vs 66,75 vs 74,78 pg/ml; p = 0,025).
Conclusion: Measuring early maternal 1,25 dihydroxy vitamin D3 can lower the pre-eclampsia risks
and the impact the perinatal outcomes, particularly in determining first Apgar scores.

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Published

2023-03-02

Issue

Vol. 7 No. 1 (2023)

Section

RESEARCH ARTICLE

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Copyright (c) 2023 Tara Fadila, Yusrawati Yusrawati, Hudila Rifa Karmia

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