The Role Of Vitamin D And Calcium In Pre-Eclampsia And The Association With Neonatal Outcomes

Authors

  • Tara Fadila Obstetrics and Gynecology Departement, Medical Faculty of M Djamil general Hospital-Andalas University, Padang, West Sumatera, Indonesia
  • Yusrawati Yusrawati Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
  • Hudila Rifa Karmia Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia

DOI:

https://doi.org/10.25077/aoj.7.1.253-266.2023

Keywords:

1, 25 dihydroxy vitamin D3, Calcium, Pre-eclampsia, Neonatal

Abstract

Introduction: Pre-eclampsia is one of the main causes of maternal and neonatal death in developing
countries. A low vitamin D level can increase the risk of neonatal abnormalities. Clinical studies
reported various complications of low vitamin D levels, such as pre-eclampsia, gestational diabetes,
low birthweight, and caesarean section. This study aimed to investigate the role of vitamin D in
pregnancy with pre-eclampsia and its association with neonatal outcomes.
Methods: This is an observational analytical study uses a cross-sectional approach to investigate
vitamin D levels and pre-eclampsia, conducted in General Hospital Dr. M. Djamil Padang from Mei
2021 – April 2022. A total of 5 mL blood was withdrawn to analyzed vitamin D. This study has been
approved by Health Research Ethics Committee Andalas University (Approved number:
339/KEPK/2021).
Results: There was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between normal
pregnancy and pre-eclampsia patients (99,18 vs 72,53 pg/ml; p = 0,033). In the pre-eclampsia patients’
first APGAR score, there was a significant difference in the levels of 1,25 dihydroxy vitamin D3 between
normal, moderate, and severe asphyxia groups (114,19 vs 66,75 vs 74,78 pg/ml; p = 0,025).
Conclusion: Measuring early maternal 1,25 dihydroxy vitamin D3 can lower the pre-eclampsia risks
and the impact the perinatal outcomes, particularly in determining first Apgar scores.

References

Achadi EL. Kematian maternal dan neonatal di indonesia. FKM UI pada Rakernas. 2019.

Organization WH. Maternal mortality: key facts. WHO [Internet]. 2019.

Behjat Sasan S, Zandvakili F, Soufizadeh N, Baybordi E. The effects of vitamin D supplement on

prevention of recurrence of preeclampsia in pregnant women with a history of preeclampsia.

Obstetrics and Gynecology International. 2017;2017.

Nassar K, Rachidi W, Janani S, Mkinsi O. Vitamin D and pre-eclampsia. Gynecol Obstet.

;6(6):1-4.

Myatt L, Roberts JM. Preeclampsia: syndrome or disease? Current hypertension reports.

;17(11):1-8.

Wibowo RHKN. Comparison of maternal vitamin D and zinc level between severe preeclampsia

and normal pregnancy in Cipto Mangunkusumo Hospital. Indonesia: Universitas Indonesia; 2014.

Mikhail N. PERBEDAAN KADAR 1, 25 DIHIDROKSI VITAMIN D3 DAN KALSIUM SERUM MATERNAL

ANTARA PREEKLAMSIA AWITAN DINI (PEAD), PREEKLAMSIA AWITAN LAMBAT (PEAL) DAN HAMIL

NORMAL: Universitas Andalas; 2018.

Harli FM. Hubungan Usia Ibu Hamil Berisiko dengan Kejadian Preeklampsia (Studi di Wilayah Kerja

Puskesmas Kabuh, Puskesmas Peterongan dan Puskesmas Cukir Kabupaten Jombang): STIKes

Insan Cendekia Medika Jombang; 2018.

Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Hypertensive

Disorders. Williams Obstetrics, 25e. New York, NY: McGraw-Hill Education; 2018.

Andriani C, Lipoeto NI, Utama BI. Hubungan Indeks Massa Tubuh dengan Kejadian Preeklampsia

di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas. 2016;5(1).

Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with

early- versus late-onset disease. Am J Obstet Gynecol. 2013;209(6):544.e1-.e12.

Aksornphusitaphong A, Phupong V. Risk factors of early and late onset pre-eclampsia. J Obstet

Gynaecol Res. 2013;39(3):627-31.

Wen Y-H, Yang H-I, Chou H-C, Chen C-Y, Hsieh W-S, Tsou K-I, et al. Association of Maternal

Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants.

Scientific Reports. 2019;9(1):13212.

Imdad A, Bhutta ZA. Effects of calcium supplementation during pregnancy on maternal, fetal and

birth outcomes. Paediatr Perinat Epidemiol. 2012;26 Suppl 1:138-52.

Hartati N. Preeklampsia dengan Berat Badan Lahir Rendah (BBLR) pada ibu bersalin. Jurnal Gema

Keperawatan. 2018;11(1).

Herzog EM, Eggink AJ, Reijnierse A, Kerkhof MA, de Krijger RR, Roks AJ, et al. Impact of early- and

late-onset preeclampsia on features of placental and newborn vascular health. Placenta.

;49:72-9.

Mihu D, Razvan C, Malutan A, Mihaela C. Evaluation of maternal systemic inflammatory response

in preeclampsia. Taiwan J Obstet Gynecol. 2015;54(2):160-6.

Downloads

Published

2023-03-02

Issue

Section

RESEARCH ARTICLE