Pregnancy with severe preeclampsia, acute kidney injury and nephrotic syndrome


  • Joserizal Serudji Department of Fetomaternal Obstetrics and Gynecology Faculty of Medicine of Andalas University/ Andalas University Hospital Padang
  • Haviz Yuad Obstetrics and Gynecology Department, Dr M. Djamil Hospital, Andalas University, Padang, West Sumatra, Indonesia;
  • Syntia Ambelina Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia



Severe preeclampsia, acute kidney injury, nephrotic syndrome.


Background: Preeclampsia is one of the main causes of maternal death every year. Preeclampsia can have bad
consequences for both the mother and the fetus. Complications in the mother in the form of HELLP syndrome
(Hemolysis, Elevated Liver Enzyme, Low Platelet), pulmonary edema, kidney disorders, bleeding, placental
abruption and even maternal death. Complications in infants can be premature birth, fetal distress, low birth
weight or intra uterine fetal death (IUFD).
Case Report: A 34 year old female patient was brought to the emergency room of Dr. M. Djamil Padang, sent to
the Batusangkar Private Hospital with complaints of shortness of breath which has been increasing when lying
down. Physical examination found blood pressure 190/136. The patient was diagnosed with G2P1A0H1 gravid
preterm 25-26 weeks, PEB on maintenance dose MgSO4 regimen from outside, suspected nephrotic syndrome,
CAP with hypoxemia, pleural effusion, AKI with metabolic acidosis, UTI, hyponatremia, hypoalbuminemia.
Discussion: Preeclampsia, eclampsia and HELLP syndrome are serious and life-threatening conditions faced by
pregnant women. Early diagnosis and prompt treatment via a multidisciplinary team in the ICU setting can
prevent complications and reduce morbidity and mortality. The most common indications for intubation and
mechanical ventilation are respiratory failure and hemodynamic instability. The cause of death in this patient
was multiple organ failure which was exacerbated by suspected nephrotic syndrome and suspected SLE.


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