A Literature Review : The Role of Genetics in Women of Reproductive Age with Anemia
Keywords:
Anemia, Genetic, Iron deficiency, TMPRSS 6, female, age of reproduction.Abstract
One of the main nutritional problems in Indonesia is anemia. Iron deficiency anemia can occur due to the interaction of two factors, namely iron intake itself and the role of genetics. The genes in humans and animals involved in iron mechanism is Transmembrane Protease Serine 6 (TMPRSS6). The purpose of this literature review is to determine the role of genetics in reproductive age women with anemia. The search was conducted with Google Schoolar database and Pubmed database looking for articles of the last 10 years from 2012 - 2022. From the number of articles found, only about 10 articles have full criteria. The results of a review of a number of articles found that there is a genetic role in women of reproductive age with anemia associated with the process of iron metabolism with the role of TMPRSS 6 gene mutations that can inhibit hepsidin activation so that it can reduce the ability to absorb iron and have an impact on the occurrence of iron deficiency anemia.
References
Permaesih D, Susilowati H. Faktor-faktor yang mempengaruhi anemia pada remaja. Buletin Penelitian Kesehatan. 2005;33(4):162-171.
Balitbangkes. Laporan Nasional Riskesdas 2018. Jakarta; 2018.
Anis M, Ratnawati Diah. Hubungan Antara Status Gizi Dengan Kejadian Anemia pada Remaja
Putri. Jurnal Ilmiah Ilmu Keperawatan Indonesia. 2019;9(1):563-570.
McLean E, Cogswell M, Egli I, Wojdyla D, De Benoist B. Worldwide prevalence of anaemia
-2005 WHO Global Database on Anemia. Public Health Nutrition. 2009:1-35.
Direktorat Gizi Masyarakat Direktorat Jenderal Kesehatan Masyarakat. Pedoman Pencegahan dan Penanggulangan Anemia Pada Remaja Putri dan Wanita Usia Subur (WUS). Kementerian
Kesehatan Republik Indonesia. 2016:10-20.
Bryan J, Osendarp S, Hughes D, Calvaresi E, Baghurst K, van Klinken J-W. Nutrients for cognitive
development in school-aged children. Nutr Rev. 2004;62(8):295–306.
Gichohi-Wainaina WN, Towers GW, Swinkels DW, Zimmermann MB, Feskens EJ, Melse- Boonstra A. Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with
meta-analyses. Genes Nutr. 2015;10(1):442.
GanW,GuanY,WuQ,AnP,ZhuJ,LuL,etal.andtype2diabetesriskinaChineseHan
population. 2012;1–4.
Sanjiwani PA. Genetic Variant Of Tmprss6, Iron Status, Psychosocial Stimulation As
Determinant Factors Of Cognitive Function Among Under Two Years Old Sasaknese CHILDREN.
Universitas Indonesia. 2016.
Lee P. Role of matriptase-2 (TMPRSS6) in iron metabolism. Acta Haematol. 2009;122(2–3):87–
Mantadakis E., Chatzimichael E., Zikidou P. Iron deficiency anemia in children residing in high
and low-income countries: risk factors, prevention, diagnosis and therapy. Mediterr J Hematol Infect Dis 2020, 12(1): e2020041.
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eISSN : 2579-8324 pISSN : 2579-8323
Elstrott, B., Khan, L., Olson, S., Raghunathan, V., DeLoughery, T. and ShatzelX J., 2019. The role of iron repletion in adult iron deficiency anemia and other diseases. European Journal of Haematology, 104(3), pp.153-161.
Putu, Yoga. Faktor yang mempengaruhi kejadian anemia defisiensi besi. Jurnal Medika Udayana. 2021.
Purwanto. 2012. Peran Hepsidin Sebagai Regulator Metabolisme Besi. Vol 4 (2): 88-95.
Chia et.al. 2014. The Role Oftmprss6/Matriptase-2 In Iron Regulation And Anemia. Vol 5 (1):
- 30.
Nasira et al. 2021. Role Of TMPRSS6 Rs855791 (T > C) Polymorphism In Reproductive Age
Women With Iron Deficiency Anemia From Lahore, Pakistan. Vol 28 (21): 748–753.
Maria et al. 2008. A Mutation In The TMPRSS6 Gene, Encoding A Transmembrane Serine Protease That Suppresses Hepcidin Production, In Familial Iron Deficiency Anemia Refractory
To Oral Iron. Vol 93 (10): 119-2227.
Habib, M.A., Raynes-Greenow, C., Soofi, S.B., Ali, N., Nausheen, S., Ahmed, I., Black, K. I., 2018.
Prevalence and determinants of iron deficiency anemia among nonpregnant women of
reproductive age in Pakistan. Asia Pacific J. Clin. Nutrit. 27 (1), 195–203.
Pei, S.-N., Ma, M.-C., You, H.-L., Fu, H.-C., Kuo, C.-Y., Rau, K.-M., Wang, M.-C., Lee, C.- T., 2014. TMPRSS6 rs855791 polymorphism influences the susceptibility to iron deficiency anemia in
women at reproductive age. Int. J. Med. Sci. 11 (6), 614– 619.
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