The Role of Magnesium Supplements on Hypertension in Pregnancy and Preeclamsia

Authors

  • Raissa Nurwany Department of Obstetrics and Gynecology, Faculty of Medicine, Sriwijaya University, Palembang, South Sumatra
  • Shafira Fitri Ramadhina Medical Professional Study Program, Faculty of Medicine, Sriwijaya University, Palembang, South Sumatra
  • Pariyana Pariyana Department of Public Health Sciences, Faculty of Medicine, Sriwijaya University, Palembang, South Sumatra

DOI:

https://doi.org/10.25077/aoj.8.1.511-518.2024

Keywords:

preeclampsia, magnesium supplements, pregnancy

Abstract

Objective:This article aims to discuss the effects of magnesium supplementation on clinical outcomes of pregnancy and highlights the benefits of magnesium supplementation in reducing the risk of hypertension in pregnancy and preeclampsia.

Method: In this systematic review article, the author conducted a literature search using certain keywords and selected articles that were published from 2013-2023, can be accessed in full-text in pdf format, and are in Indonesian or English. The methods used were in accordance with the reporting guidelines provided in the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P).

Results: After carefully searching the database and eliminating articles that were not related to the topic, 6 articles were obtained for review. Hypertension in pregnancy and preeclampsia are serious health problems that can harm both mother and baby. Magnesium supplements have been studied as a way to reduce the risk of hypertension in pregnancy and preeclampsia.

Conclusion: Magnesium supplements may help reduce the risk of hypertension in pregnancy and preeclampsia.

References

Ilham M, Akbar A, Ernawati E, Dachlan EG. The Hypertension in Pregnancy Problems in Indonesia. ResearchGate,(April). Published online 2019:4-8.

Khan B, Yar RA, khan Khakwani A, et al. Preeclampsia Incidence and Its Maternal and Neonatal Outcomes With Associated Risk Factors. Cureus. 2022;14(11).

Wahyunindita RN, Sari RDP. Severe Pre-Eclampsia with Partial Hellp Syndrome in Multigravida Preterm Pregnancy. Indonesian Journal of Global Health Research. 2022;4(1):1-8.

Fox R, Kitt J, Leeson P, Aye CYL, Lewandowski AJ. Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring. J Clin Med. 2019;8(10):1625.

Karrar SA, Hong PL. Preeclampsia. In: StatPearls [Internet]. StatPearls Publishing; 2022.

de Araújo CAL, de Sousa Oliveira L, de Gusmão IMB, Guimarães A, Ribeiro M, Alves JGB. Magnesium supplementation and preeclampsia in low-income pregnant women–a randomized double-blind clinical trial. BMC Pregnancy Childbirth. 2020;20:1-6.

Diamanti M, Facchinetti F. Magnesium supplementation in Obstetrics and Gynaecology: a brief review. ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS. 2020;32(4):269-275.

Zarean E, Tarjan A. Effect of Magnesium Supplement on Pregnancy Outcomes: A Randomized Control Trial. Adv Biomed Res. 2017;6(1):109.

Yulia Darma I, Dana Nindrea R, Idaman M, Zaimy S, Irman V, Tinggi S, et al. The Effect of Magnesium Supplementation and Pregnancy Outcomes: Experimental Epidemiological Study. 2021;39(SeSICNiMPH):198–204.

Bullarbo M, Mattson H, Broman AK, Ödman N, Nielsen TF. Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study. J Pregnancy. 2018;2018.

De Araújo CAL, De Sousa Oliveira L, De Gusmão IMB, Guimarães A, Ribeiro M, Alves JGB. Magnesium supplementation and preeclampsia in low-income pregnant women - A randomized double-blind clinical trial. BMC Pregnancy Childbirth. 2020;20(1):1–6.

Makrides M, Crosby DD, Bain E, Crowther CA. Magnesium supplementation in pregnancy. Cochrane Database Syst Rev. 2014;2014(4).

Atiba AS, Akindele RA, Bello NO, Kolawole OO, Fasanu AO. Serum Magnesium Levels in Second and Third Trimesters of Pregnancy in Patients That Developed Pre-Eclampsia and Feto-Maternal Outcome. Open J Obstet Gynecol. 2020;10(01):108–17.

Porri D, Biesalski HK, Limitone A, Bertuzzo L, Cena H. Effect of magnesium supplementation on women’s health and well-being. NFS J [Internet]. 2021;23(April):30–6. Available from: https://doi.org/10.1016/j.nfs.2021.03.003

Irwinda R. Peran Kalsium dan Magnesium pada Kehamilan. Medicinus. 2020;33(1):3–7.

Dalton LM, Ní Fhloinn DM, Gaydadzhieva GT, Mazurkiewicz OM, Leeson H, Wright CP. Magnesium in pregnancy. Nutr Rev. 2016;74(9):549–57.

Kharb S, Goel K, Bhardwaj J, Nanda S. Role of magnesium in preeclampsia. Biomedical and Biotechnology Research Journal (BBRJ). 2018;2(3):178. doi:10.4103/bbrj.bbrj_70_18.

Fanni D, Gerosa C, Nurchi VM, Manchia M, Saba L, Coghe F, et al. The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases. Biol Trace Elem Res. 2021;199(10):3647–57.

Berghella V. Maternal-Fetal Evidence Based Guidelines. CRC Press; 2022.

Anand S, Hak J, Prashar N, Gandotra N, Jaggi R. The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital. Int J Reprod Contracept Obstet Gynecol. 2019;8(9):3543-3550.

Chiarello DI, Marín R, Proverbio F, et al. Mechanisms of the effect of magnesium salts in preeclampsia. Placenta. 2018;69:134-139. doi:10.1016/j.placenta.2018.04.011.

Schoenaker DAJM, Soedamah-Muthu SS, Mishra GD. The association between dietary factors and gestational hypertension and pre-eclampsia: a systematic review and meta-analysis of observational studies. BMC Med. 2014;12(1):1-18.

Rylander R, Vormann J. Magnesium intervention studies-methodological aspects. Magnes Res. 2015;28(2):75-78.

Jaiswal AK, Kumar R, Bisht K, Sharma DK, Gupta M. Magnesium poisoning with analytical aspects and its management. Indian J Forensic Community Med. 2020;7(2):51–5.

Mochizuki M, Akagi K, Inoue K, Shimamura K. [A single dose toxicity study of magnesium sulfate in rats and dogs]. J Toxicol Sci. 1998 May;23 Suppl 1:31–5.

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Published

2024-01-30

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Section

LITERATURE REVIEW