PAPP-A Levels and IGF-1 Levels in Early-Onset Preeclampsia and Late-Onset Preeclampsia

Authors

  • Juan Habli Soufal Residen of Departement of Obstetrics and Gynecology, RSUP Dr. M. Djamil, Padang, Indonesia;
  • Yusrawati Yusrawati Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
  • Vaulinne Basyir Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia

DOI:

https://doi.org/10.25077/aoj.8.1.519-524.2024

Keywords:

Physiology, pregnancy, pathogenesis, signs

Abstract

Introduction: The pathophysiology of preeclampsy is not yet fully understood, but failure of tropoblast invasion and placentation, which is influenced by factors such as pregnancy-associated plasma protein A (PAPP-A) and insulin-like growth factor 1 (IGF-1), is thought to play a role.


Aims: This study aimed to explore the difference in PAPP-A and IGF-1 levels between Early-Onset Preeclampsia (PEAD) and Late-Onset Preeclampsia (PEAL), assuming that the role of PAPP-A and IGF-1 is more significant in the pathogenesis of PEAD than PEAL.


Methods: This is an analytical observational study with a cross-partition comparative study design. Clinical data were obtained at Dr. M. Djamil Padang Hospital, while PAPP-A and IGF-1 levels were measured at the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Samples are tested according to reagent procedures and analyzed by experts.
Results: Average PAPP-A levels were 2.45+0.35 pg/mL in the early onset preeclampsy group and 2.85+0.50 pg/mL in the late onset preeclampsy group. These two levels differed statistically significantly (p=0.006). That means that low levels of PAPP-A are associated with and play a role in the pathogenesis of early onset preeclampsy. Average IGF-1 levels were 4.66+0.91 pg/mL in the early onset preeclampsy group and 5.39+0.74 pg/mL in the late-onset preeclampsy group. These two levels differed statistically significantly (p=0.010). That means that low levels of IGF-1 are associated with and play a role in the pathogenesis of early onset preeclampsy. PAPP-A levels were significantly positively correlated with IGF-1 levels (p=0.000).


Conclusion: PAPP-A levels are lower in PEAD than PEAL, as are IGF-1 levels. These findings confirm the role of PAPP-A and IGF-1 in preeclampsia. Both of these hormones have potential as indicators and markers for the prediction and management of preeclampsy in early and late onset periods.

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Published

2024-01-30

Issue

Vol. 8 No. 1 (2024)

Section

RESEARCH ARTICLE

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Copyright (c) 2024 Juan Habli Soufal, Yusrawati Yusrawati, Vaulinne Basyir

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