PAPP-A Levels and IGF-1 Levels in Early-Onset Preeclampsia and Late-Onset Preeclampsia
(1) Residen of Departement of Obstetrics and Gynecology, RSUP Dr. M. Djamil, Padang, Indonesia;
(2) Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
(3) Sub Division of Fetomaternal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang, West Sumatera, Indonesia
(*) Corresponding Author
DOI: https://doi.org/10.25077/aoj.8.1.525-530.2024
Abstract
Introduction: The pathophysiology of preeclampsy is not yet fully understood, but failure of tropoblast
invasion and placentation, which is influenced by factors such as pregnancy-associated plasma protein
A (PAPP-A) and insulin-like growth factor 1 (IGF-1), is thought to play a role.
Aims: This study aimed to explore the difference in PAPP-A and IGF-1 levels between Early Onset
Preeclampsia (PEAD) and Late Onset Preeclampsia (PEAL) assuming that the role of PAPP-A and
IGF-1 is more significant in the pathogenesis of PEAD than PEAL.
Methods: This is an analytical observational study with a cross-partition comparative study design.
Clinical data were obtained at Dr. M. Djamil Padang Hospital, while PAPP-A and IGF-1 levels were
measured at the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Samples are
tested according to reagent procedures and analyzed by experts.
Results: Average PAPP-A levels were 2.45+0.35 pg/mL in the early onset preeclampsy group and
2.85+0.50 pg/mL in the late onset preeclampsy group. These two levels differed statistically
significantly (p=0.006). That means that low levels of PAPP-A are associated with and play a role in
the pathogenesis of early onset preeclampsy. Average IGF-1 levels were 4.66+0.91 pg/mL in the early
onset preeclampsy group and 5.39+0.74 pg/mL in the late-onset preeclampsy group. These two levels
differed statistically significantly (p=0.010). That means that low levels of IGF-1 are associated with
and play a role in the pathogenesis of early onset preeclampsy. PAPP-A levels were significantly
positively correlated with IGF-1 levels (p=0.000).
Conclusion: PAPP-A levels are lower in PEAD than PEAL, as are IGF-1 levels. These findings confirm
the role of PAPP-A and IGF-1 in preeclampsia. Both of these hormones have potential as indicators
and markers for the prediction and management of preeclampsy in early and late onset periods.
Keywords
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