• Muhammad Ryfki SA Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/ Dr. M. Djamil General Hospital, Padang
  • Roza Sri Yanti Subdivision of Fetomaternal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/ Dr. M. Djamil Hospital Padang
  • Bobby Indra Utama Subdivision of Urogynecology and Reconstructive Surgery, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/ Dr. M. Djamil Hospital Padang



Partus Prematurus Iminens, Vaginal microbiota


One of the threats in pregnancy is threatened preterm labor. Several studies show that the
composition of the microbiota in the vagina of premature births and normal pregnancies is different.
This study aims to determine the comparison of microbiota in pregnancies with premature parturition
and normal pregnancies at Dr M Djamil General Hospital, Padang. This research is an analytical
observational study with a case–control study design conducted at the Department/SMF of Obstetrics
and Gynecology, RSUP Dr. M. Djamil Padang from July – September 2023. The study population in this
research were all pregnant women with a gestational age of 20-37 weeks who were diagnosed with
imminens preterm labor and normal pregnant women with a gestational age of 20-37 weeks who
received antenatal care at RSUP Dr. M. Djamil Padang. Respondents had vaginal swabs taken for
microbiological culture at the Biomedical Laboratory, Andalas University, Padang. There were 33
respondents each in the imminence premature birth and normal pregnancy groups. Vaginal swab
results showed that the most common microorganism found in normal pregnancy was Lactobacilus
sp. (73%) while in threatened preterm labor Staphylococcus aureus (37%), Staphylococcus epidermidis
(27%) and E.coli (15%) were more commonly found with only a small proportion of Lactobacilus sp
(12%). Chi square analysis showed a significant difference between the vaginal microbiota of normal
pregnant women and pregnant women with PPI. The conclusion of this study is that there is an
increase in Staphylococcus aureus, Staphylococcus epidermidis and E.coli in pregnant women on PPI
with a decrease in the number of normal flora, namely Lactobacilus spp.


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