Clinical Characteristics, Laboratory, Maternal and Fetal Outcomes in Pregnancy with Covid-19 at RSUP dr. M. Djamil Padang
DOI:
https://doi.org/10.25077/aoj.8.1.569-578.2024Keywords:
Clinical Characteristics, Covid-19, Laboratory, Maternal, Fetal OutcomesAbstract
Introduction : The data obtained from various studies about covid-19 conducted in several hospitals in the world are currently considered not sufficient to provide a clinical picture that occurs in pregnancies with Covid-19 infection. The aims to provide an overview of the clinical, laboratory, maternal and fetal outcomes in pregnancy with Covid-19 infection at dr. M. Djamil Padang.
Methods: This study used a descriptive design with data collection starting from March 01, 2020 - March 31, 2021 based on medical record data. Carried out in a single center at RSUP dr. M. Djamil Padang in pregnant patients with confirmed Covid-19 by PCR examination.
Results: Total 136 pregnant patients confirmed Covid-19 by PCR examination. Most of the symptoms were asymptomatic (47.1%) and without any comorbidities (76.5%). There were 3 patients who experienced critical symptoms (2.2%). Maternal mortality was found at 2.3% and fetal death 4.7%. The values of d-dimer and NLR were found increasing significantly, 2025.35±1392.18 for d-dimer and 6.39±4.43 for NLR. Pregnancy terminations done for 77.9% patients with cesarean section is the most method (83%). There were 4 cases (3.8%) of babies infected with Covid-19 from mothers who had pregnancy terminations.
Conclusions: Most cases had asymptomatic clinical symptoms (47.1%). There are 2.3% cases of maternal death and 4.7% cases of fetal death. Most of the pregnancy terminations were performed by cesarean section (88%). On laboratory examination, there was a significant increase in maternal d-dimer (2,025.35±1.392.18) and NLR (6.39±4.43) in pregnancies with Covid-19.
References
Yap M, Debenham L, Kew T, Chatterjee S, Allotey J, Stallings E. Clinical
manifestations, prevalence, risk factors, outcomes, transmission, diagnosis and
treatment of covid-19 in pregnancy and postpartum: a living systematic review protocol.
BMJ Open. 2020;10(12):1–6.
Covid-19 S. Data Covid-19 di Indonesia [Internet]. Badan Nasional Penanganan
Bencana. 2021 [cited 2021 Feb 28]. p. 1. Available from: https://covid19.go.id
Monteleone P, Nakano M, Lazar V, Gomes A, Bonetti T. A review of initial data on
pregnancy during the covid-19 outbreak: implications for assisted reproductive
treatments. JBRA Assist Reprod. 2020;24(2):219–25.
Hassanipour S, Faradonbeh SB, Momeni K, Heidarifard Z, Khosousi M-J, Khosousi L,
et al. A systematic review and meta-analysis of pregnancy and COVID-19: Signs and
symptoms, laboratory tests, and perinatal outcomes. Int J Reprod Biomed. 2020
Dec;18(12):1005–18.
Bachani S, Arora R, Dabral A, Marwah S, Anand P, Reddy KS, et al. Clinical Profile,
Viral Load, Maternal-Fetal Outcomes of Pregnancy With COVID-19: 4-Week
Retrospective, Tertiary Care Single-Centre Descriptive Study. J Obstet Gynaecol
Canada. 2021 Apr;43(4):474–82.
Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy:
a systematic review. J Matern neonatal Med. 2022 Apr;35(8):1619–22.
Kucirka LM, Norton A, Sheffield JS. Severity of COVID-19 in pregnancy: A review of
current evidence. Am J Reprod Immunol. 2020 Nov;84(5):e13332.
Ashraf MA, Keshavarz P, Hosseinpour P, Erfani A, Roshanshad A, Pourdast A, et al.
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the
Possibility of Vertical Transmission. J Reprod Infertil [Internet]. 2020;21(3):157–68.
Available from: https://pubmed.ncbi.nlm.nih.gov/32685412
Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease
(COVID-19) pandemic and pregnancy. Am J Obstet Gynecol [Internet].
;222(6):521–31. Available from: https://doi.org/10.1016/j.ajog.2020.03.021
Debrabandere ML, Farabaugh DC, Giordano C. A Review on Mode of Delivery during
COVID-19 between December 2019 and April 2020. Am J Perinatol. 2021
Mar;38(4):332–41.
Ortiz EI, Herrera E, De La Torre A. Coronavirus (COVID 19) Infection in Pregnancy.
Colomb medica (Cali, Colomb. 2020 Jun;51(2):e4271.
Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A
systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020
Jul;99(7):823–9.
Erol Koç EM, Fındık RB, Akkaya H, Karadağ I, Tokalıoğlu EÖ, Tekin ÖM. Comparison
of hematological parameters and perinatal outcomes between COVID-19 pregnancies
and healthy pregnancy cohort. J Perinat Med. 2021 Feb;49(2):141–7.
Cunningham F, Leveno K, Bloom S, Dashe J, Hoffman B, Casey B. William’s
Obstetrics. New York: McGraw Hill; 2018. 943–52 p.
Kadir RA, Kobayashi T, Iba T, Erez O, Thachil J, Kazi S, et al. COVID-19 coagulopathy
in pregnancy: Critical review, preliminary recommendations, and ISTH registryCommunication from the ISTH SSC for Women’s Health. J Thromb Haemost. 2020
Nov;18(11):3086–98.
Mattar CN, Kalimuddin S, Sadarangani SP, Tagore S, Thain S, Thoon KC, et al.
Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore. Ann
Acad Med Singapore. 2020 Nov;49(11):857–69.
Magee LA, Khalil A, von Dadelszen P. Pregnancy hypertension diagnosis and care in
COVID-19 era and beyond. Ultrasound Obstet Gynecol. 2020 Jul;56(1):7–10.
Tug N, Yassa M, Köle E, Sakin Ö, Çakır Köle M, Karateke A, et al. Pregnancy worsens
the morbidity of COVID-19 and this effect becomes more prominent as pregnancy
advances. Turkish J Obstet Gynecol [Internet]. 2020/10/02. 2020 Sep;17(3):149–54.
Available from: https://pubmed.ncbi.nlm.nih.gov/33072417
Chen L, Jiang H, Zhao Y. Pregnancy with COVID-19: Management considerations for
care of severe and critically ill cases. Am J Reprod Immunol. 2020 Nov;84(5):e13299.
Vergara-Merino L, Meza N, Couve-Pérez C, Carrasco C, Ortiz-Muñoz L, Madrid E, et
al. Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview
of systematic reviews. Acta Obstet Gynecol Scand. 2021 Jul;100(7):1200–18.
Lopes de Sousa ÃF, Carvalho HEF de, Oliveira LB de, Schneider G, Camargo ELS,
Watanabe E, et al. Effects of COVID-19 Infection during Pregnancy and Neonatal
Prognosis: What Is the Evidence? Int J Environ Res Public Health [Internet]. 2020 Jun
;17(11):4176. Available from: https://pubmed.ncbi.nlm.nih.gov/32545378
Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe
COVID-19 during Pregnancy and Possible Vertical Transmission. Am J Perinatol. 2020
Jun;37(8):861–5.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Roza Sriyanti, Heri Farnas, Dovy Djanas
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Authors who publish with this journal agree to the following terms:
- Authors retain the copyright of published articles and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
License:
Andalas Obstetrics and Gynecology Journal (AOJ) is published under the terms of the Creative Commons Attribution 4.0 International License. This license permits anyone to copy and redistribute this material in any form or format, compose, modify, and make derivatives of this material for any purpose, including commercial purposes, as long as they credit the author for the original work.
