The Effect of Giving Prophylactic Antibiotic Ceftriaxone and Cefazolin and Giving Ceftriaxone Before and After Surgery to The Risk of Postoperative Wound Infection in Postoperative Patients

Herti Marni(1*), Dovy Djanas(2), Hafni Bachtiar(3)

(1) Resident of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(2) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(3) Public Health Department, Faculty of Medicine, Andalas University Padang
(*) Corresponding Author

DOI: https://doi.org/10.25077/aoj.4.1.77-86.2020

Abstract


Objective : To determine the effect of giving prophylactic antibiotic ceftriaxone and cefazolin and giving ceftriaxone before and after surgery to the risk of postoperative wound infection in postoperative patients.

Method: This study was an experimental study with a post test control group design that looked at the differences in the effect of administration of ceftriaxone, cefazolin, and ceftriaxone before and after surgery on the risk of postoperative wound infection. The population in this study were patients planned for surgery in the Obstetric and Gynelologic Departement of Dr. M. Djamil General Hopital, Padang. The number of samples used by 30 people with a group of 10 people each group. The study began in August until the number of samples was fulfilled. Univariate analysis was used to see the frequency, percentage, mean, and standard deviation. Bivariate analysis using Chi-square test with 95% CI (α <0.05) was used to see differences in the effect of the three antibiotic procedures.

Results: There were no cases of postoperative wound infection based on the three procedures used. There was no difference in the effect of prophylactic antibiotics in postoperative infections. Conclusion: There was no difference in the effect of the three procedures for prophylactic antibiotics in postoperative infections.

Keywords: Prophylactic Antibiotics, Surgical Wound Infections, Cefazolin, Ceftriaxone, Superficial incisional SSI

Full Text:

PDF

References


WHO. Global guidelines for the prevention of surgical site infection. J Hosp Infect. 2017;95(2):135–6

Marni H, Djanas D. Pola Bakteri dan Sensitivitasnya Terhadap Antibiotik pada Pasien Rawat Inap Bagian Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang pada Bulan Mei 2017-Mei 2018. Universitas Andalas; 2018.

Center for Disease Control and Prevention. Procedure-associated Module SSI (Surgical Site Infection). 2019.

Van Schalkwyk J, Van Eyk N. Antibiotic Prophylaxis in Obstetric Procedures. J Obstet Gynaecol Canada. 2017;39(9):e293–9.

American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Prevention of Infection After Gynecologic Procedures. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 172–89.

American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Use of Prophylactic Antibiotics in Labor and Delivery. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 103–19.

Kusaba T. Safety and Efficacy of Cefazolin Sodium in the Management of Bacterial Infection and in Surgical Prophylaxis. Clin Med Ther. 2009;1607–15.

Marathias SGK, Kadas JKB. Cephalosporins in Surgical Prophylaxis. J Chemother. 2001;13(1):23–6.

Thelwall S, Harrington P, Sheridan E, Lamagni T. Impact of obesity on the risk of wound infection following surgery: Results from a nationwide prospective multicentre cohort study in England. Clin Microbiol Infect [Internet]. 2015;21(11):1008.e1-1008.e8. Available from: http://dx.doi.org/10.1016/j.cmi.2015.07.003

Agodi A, Quattrocchi A, Barchitta M, Adornetto V, Cocuzza A, Latino R, et al. Risk of surgical site infection in older patients in a cohort survey: Targets for quality improvement in antibiotic prophylaxis. Int Surg. 2015;100(3):473–9.

Aditya R. Faktor Risiko Infeksi Luka Operasi Bagian Obstetri dan Ginekologi RSUD Ulin Banjarmasin. J Berk Kesehat. 2018;4(1):10–7.

Assawapalanggool S, Kasatpibal N, Sirichotiyakul S, Arora R, Suntornlimsiri W, Apisarnthanara. The efficacy of ampicillin compared with ceftriaxone on preventing caesarean surgical site infection: an observational prospective cohort study. Antimicrob Resist Infect Control. 2018;22(7):1–8.

American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetricians & Gynecologists-Prevention of Infection After Gynecologic Procedures. In: Obstetrics & Gynecology. Washington DC: ACOG; 2018. p. 172–89.

Mehta D, Sharma AK. Cephalosporins: A Review on Imperative Class of Antibiotics. Inven Rapid Mol Pharmacol. 2015;2016(1):1–6.

Masoud MS, Ali AE, Nasr NM. Chemistry, classification, pharmacokinetics, clinical uses and analysis of beta lactam antibiotics : A review. J Chem Pharm Res. 2014;6(11):28–58.

Chiu C, Su L, Huang Y, Lai J, Chen H, Wu T, et al. Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan ᰔ. 2007;51(9):3404–6.

Muller A, Bertrand X, Talon D. Relationship between ceftriaxone use and resistance to third-generation cephalosporin among clinical strainsof E. cloacae. J Antimicrob Chemother. 2004;54(1):173–7.

Perkumpulan Obstetri Ginekologi Indonesia. Panduan Antibiotika Profilaksis Pada Pembedahan Obstetri dan Ginekologi. Jakarta; 2013.

Yulia R, Herawati F, Jaelani A, Anggraini W. Evaluasi penggunaan antibiotik dan profil kuman pada seksio sesarea di Rumah Sakit Umum Daerah Kabupaten Pasuruan. J Farm Klin Indones. 2018;7(2):69–77.

Hamidy MY, Fauzia D, Nugraha DP, Muttaqien MI. Penggunaan Antibiotik Profilaksis Bedah pada Sectio Cesarea di RSUD Arifin Achmad Provinsi Riau. JIK. 2016;10(1):33–7


Refbacks

  • There are currently no refbacks.




Address for Correspondence:

Editorial Room Andalas Obstetrics and Gynecology Journal 3rd floor of KSM Obstetrics and Gynecology
RSUP Dr. M. Djamil Padang, Jl. Perintis Kemerdekaan Padang, Sumatara Barat, 25127