The Relationship Between Magnesium Level in Pregnancy with Gestational Diabetes Mellitus

Syntia Ambelina(1*), Dovy Djanas(2), Hafni Bachtiar(3)

(1) Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(2) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(3) Public Health Department, Faculty of Medicine, Andalas University Padang
(*) Corresponding Author

DOI: https://doi.org/10.25077/aoj.5.1.102-111.2021

Abstract


Introduction : Magnesium is one of important micronutrients in pregnancy. Pregnant women needs higher magnesium intake than non-pregnant women at similar age. Decreased blood and cellular magnesium level was related to insulin resistance.

Objective : To determine relationship between mean magnesium level in pregnant women with incidence of gestational diabetes mellitus.

Methods : This was quantitative analytic study using cross sectional comparative design conducted in 8 Primary Health Care in Padang and 5 General Hospital in West Sumatra. This study was done from December 2019 until March 2020. Total sample collected was 36 samples consisted of 18 pregnant mother with gestational diabetes mellitus and 18 control sample with normal pregnancy, both were in gestational age between 24-28 weeks. Statistical analysis was done using independent sample T-test.

Results : Mean magnesium level of pregnant mother with gestational diabetes mellitus was 1.85 ± 0.12 mg/dL, while in control sample was 2.10 ± 0.15 mg/dL. Statistical result using independent sample T-test showed significant correlation between mean magnesium level and incidence of gestational diabetes mellitus with p <0.001 (p value <0.05)

Conclusion : Magnesium level during pregnancy is related to gestational diabetes mellitus incidence.

Keywords: magnesium level, pregnant women, gestational diabetes mellitus


Full Text:

PDF

References


ASEAN. Asean statistical report on millennium development goals. 2017

Kemenkes RI. Data dan informasi profil kesehatan Indonesia 2017. Infodatin. 2017.

Syaikh K, Das CM, Baloch GH, Abbas T, Fazlani K and Jaffery MH. Magnesium associated complications in pregnant women. World Appl. Sci. J. 2012; 17(9): 1074-78.

Lammi-Keefe, Carol & Couch, Sarah & H. Philipson, Elliot. Handbook of Nutrition and Pregnancy. 2008; 191-109.

Lynne M. Dalton, Deirdre M. Ni Fhloinn, Gergana T. Gaydadzhieva, Ola M. Mazurkiewicz, Heather Leeson, Ciara P. Wright. Magnesium in Pregnancy. Nutrition Reviews. 2016; 74(9): 549–557.

Dalton LM, Fhloinn DM, Gaydadzhieva GT, Mazurkiewicz OM, Leason H and Wright CP. Magnesium in Pregnancy. Nutrition review. 2016; 74 (9): 549-557.

Chiarello DI, Marin R, Proverbio F, Coronado P, Toledo F, Salsoso R, et al. Mechanisms of the Effects of Magnesium Salts in Preeclampsia. Placenta. 2018; 69: 134-139.

Namitha Vijay. Evaluation of Serum Magnesium Level in Pregnant Women with and without Gestational Diabetes Mellitus. International Journal of Biochemistry and Biophysics. 2018; 6(2): 33-36.

American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus [published correction appears in Diabetes Care. 2010 Apr;33(4):e57]. Diabetes Care. 2010;33 Suppl 1(Suppl 1):S62–S69.

Abadi Agus. Panduan Penatalaksanaan Kehamilan dengan Diabetes Melitus. 2010. Diunduh dari: https://pogi.or.id/publish/download/pnpk-dan-ppk/.

Cunningham, et al. Diabetes Mellitus Chapter 57. Williams Obstetrics 25th edition. 2018.

Yang SJ, Hwang SY, Baik SH, Lee KW, Nam MS, Park YS et al. Serum Magnesium Level is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus:The Korea National Diabetes Program Study. J Korean Med Sci. 2014;29:84-9.

Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. J Lab Physicians 2015;7:75-8.

Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015; 7(9): 8199-226.

Mishu FA, Muttalib MA, Naher S, Tabassum R, Ahmed R, Aziz Z, Wahab MAKA, Akhter S, Khan MRA. Serum Magnesium Level in Gestational Diabetes Mellitus in a Tertiary Care Hospital of Bangladesh. Bangladesh Journal of Medical Biochemistry. 2016;(9):59-62.

Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on Physiological, Clinical and Analytical Aspects. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2000 Apr;294(1-2):1-26.

Baloch GH, Khalida S, Mukhtiar HJ, Tahir A, Chandr MD, Bikha RD, Syed ZAS, Kashif F. Serum Magnesium Level During Pregnancy. World Applied Sciences Journal. World Applied Sciences Journal. 2012; 17 (8): 1005-1008.

Bardicef M, Bardicef O, Sorokin Y, Altura BM, Altura BT, Cotton D B and Resnick LM. Extracelluar and Intracellular Magnesium Depletion in Pregnancy and Gestational Diabetes. Am J Obst Gynecol. 1995; 172: 1009.

Takaya J, Yamato F and Kanelco K. Possible Relationship Between Low Birth Weight and Magnesium Status: from the Standpoint of Fetal Origin Hypothesis. Magnes Res. 2006; 19: 630-9.

Wang Y, Tan M, Huang Z, Sheng L, Ge Y, Zhang H, Jiang M. Elemental Contents in Serum of Pregnant Women with Gestational Diabetes Mellitus. Biol Trace Elem Res. 2002; 88(2): 113-118.

Musavi H, Mohammadi Tahroodi F, Fesahat F, et al. Investigating the Relationship between Magnesium levels and Diabetes Mellitus in Pregnant Women. Int J Mol Cell Med. 2019; 8(3):223-231.

Nabouli MR, Lassoued L, Bakri Z, Moghannem M. Modification of Total Magnesium Level in Pregnant Saudi Women Developing Gestational Diabetes Mellitus. Diabetes & Metabolic Syndrome. 2016 Oct - Dec;10(4):183-185.

Kim DJ, Xun P, Liu K, Loria C, Yokota K, Jacobs DR et al. Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence Of Diabetes. Diabetes Care. 2010;33:2604-10.

Song Y, Li TY, Van Dam RM, Manson JE, Hu FB. Magnesium Intake and Plasma Concentration of Markers of Systemic Inflammation and Endothelial Dysfunction in Women. Am J Clin Nutr. 2007;85:1068-74.

He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L et al. Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults. Circulation. 2006;113:1675-82.

Mishu AF, Muttalib AM. Serum Magnesium and Copper in Bangladeshi Women with Gestational Diabetes Mellitus. IMC J Med Sci. 2017; 11(1):25-8.

Al-Auqbi TFR, Al-Mussawi AMR, Al- Sammraie AMR. Serum Copper, Zinc and Cu/ Zn Ratio in Diabetes. Iraqi J. Comm. Med. 2008; 21(1)64-8.

Yang SJ, Hwang SY, Baik SH, et al. Serum Magnesium Level is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study. J Korean Med Sci. 2014; 29(1):84-89.

Paolisso G, Scheen A, D'Onofrio F, Lefèbvre P. Magnesium and Glucose Homeostasis. Diabetologia. 1990; 33:511–514.

Takaya J, Higashino H, Kobayashi Y. Intracellular Magnesium and Insulin Resistance. Magnes Res. 2004; 17:126–136.

Asemi Z, Karamali M, Jamilian M, et al. Magnesium Supplementation Affects Metabolic Status and Pregnancy Outcomes in Gestational Diabetes: a Randomized, Double-Blind, Placebo-Controlled Trial. Am J Clin Nutr. 2015;102(1):222-229.


Refbacks

  • There are currently no refbacks.




Address for Correspondence:

Editorial Room Andalas Obstetrics and Gynecology Journal 3rd floor of KSM Obstetrics and Gynecology
RSUP Dr. M. Djamil Padang, Jl. Perintis Kemerdekaan Padang, Sumatara Barat, 25127