Correlation of Ferritine and Brain Derived Neurotrophic Factor (BDNF) Levels in Preeclampsia
(1) Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(2) Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(3) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(*) Corresponding Author
DOI: https://doi.org/10.25077/aoj.5.2.161-177.2021
Abstract
Iron deficiency anemia that followed by low serum ferritin levels in early pregnancy has an indirect impact on decreasing the expression of Brain Derived Neurotrophic Factor (BDNF) in the maternal hippocampus. BDNF together with its receptor tyrosine kinase B (TrkB) induced the expression of metalloproteinase-9 (MMP-9) which plays an important role in blastocyst implantation, trophoblast invasion and placental development. Decreasing BDNF levels can interfere with those process which caused imbalance of pro-angiogenic and anti-angiogenic factors such as VEGF, PIGF, sFlt1 and sEng that leads to preeclampsia. This study aims to determine the correlation between ferritin and BDNF serum levels in preeclampsia.
Keywords: Preeclampsia, ferritin, iron deficiency anemia, Brain Derived Neurotrophic FactorFull Text:
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Rana Sarosh, et al. Compendium of Pathophysiology and Treatment of Hipertension, Preeclampsia: Pathophysiology, Challenges, and Perspektive. AHA Journals. 2020.
American College of Obstetricians and Gynecologists. Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122:1122–1131.
Perkumpulan Obstetri dan Ginekologi Indoensia. Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tatalaksana Preeclampsia. Jakarta: POGI Himpunan Kedokteran Fetomaternal: 2016.
Einarsson JI, Sangi-Haghpeykar H, Gardner NO. Sperm exposure and development of preeclampsia. Am J Obstet Gynecol. 2003;188:1241-3.
Belammy L, Casas JP, Hingorani AD, Williams DJ. Preeclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335:974.
Kaur, M., Chauhan, A., Manzar, M. D., & Rajput, M. M. (2015). Maternal Anaemia and Neonatal Outcome: A Prospective Study on Urban Pregnant Women. Journal of clinical and diagnostic research: JCDR, 9(12), QC04.
World Health Organization. Iron Deficiency Anaemia Assessment, Prevention, and Control: A guide for programme managers.
Desby Juananda, Dwi Cahyani Ratna Sari, Djoko Prakos, Nur Arfian, Mansyur Romi. Pengaruh Stres Kronik terhadap Otak: Kajian Biomolekuler Hormon Glukokortikoid dan Regulasi Brain-Derived Neurotrophic Factor (BDNF) Pascastres di Cerebellum. JIK 2015. Jilid 9, Nomor 2: Hal. 65-70.
Lisa M. Christian, Amanda M. Mitchell, Shannon L. Gillespie, and Marilly Palettas. Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: Associations with race, depressive symptoms, and low birth weight. Psychoneuroendocrinology. 2016 December ; 74: 69–76. doi:10.1016/j.psyneuen.2016.08.025
Bathina et al. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 2015; 11, 6: 1164–1178
Tran et al. Early-Life Iron Deficiency Anemia Alters Neurotrophic Factor Expression and Hippocampal Neuron Differentiation in Male Rats. J. Nutr. 138: 2495–2501, 2008.
Estrada et al. Molecular mechanisms of cognitive impairment in iron deficiency: Alterations in brain-derived neurotrophic factor and Insulinlike growth factor expression and function in the central nervous system. Nutritional Neuroscience 2014 Vol. 17 No. 5. Hh 193-206.
Tran et al. Long-Term Reduction of Hippocampal Brain-Derived Neurotrophic Factor Activity After Fetal-Neonatal Iron Deficiency in Adult Rats. Pediatric Research. 2009. Vol. 65, No. 5.
Sara M, et al. Iron administration prevents BDNF decrease and depressive-like behavior following chronic stress. J brainres. 2014.10.057.
Flora et al. Correlation Between Brain-Derived Neurotrophic Factor Levels and Serum Iron Levels in Stunted Children Living in Malaria-Endemic Areas. Journal of Medical Sciences. 2020 May 10; 8(E):318-321
Cunningham, FG. Protocols for High-Risk Pregnancies: An Evidence-Based Approach. Fifth Edition. Dallas:2010.
Aljafar et al. HWA: Hypoferritinemia without anemia a hidden hematology disorder. J Family Med Prim Care. 2017 Jan-Mar; 6(1): 69–72.
Metelli G, Polacchini A. A method for reproducible measurements of serum BDNF: comparison of the performance of six commersial assays. Scientific Reports. 2015. 5: 17988.
Shayan et al. redictors of Preeclampsia Based on a 10-Year Case-Control Study. Journal of family and Reproductive Health. 2019. Vol. 13, No. 1.
Berek JS, Novak E. Berek and Novak's Gynecology: 15th ed. Lippincott Williams & Wilkins, 2012.
Magnus P, Eskild A. Seasonal variation in the occurrence of pre-eclampsia. BJOG 2001; 108:1116-9.
Tyas et al. Risk factor of severe preeclampsia in Dr. Soetomo Hospital Surabaya in 2015. Majalah Obstetri & Ginekologi, Vol. 25 No. 1 April 2017: 6-9.
Raymond D, Peterson E. A critical review of early-onset and late-onset preeklampsia. Obstet Gynecol Surv. 2011 Aug;66(8):497-506. doi: 10.1097/OGX.0b013e3182331028.
Kartika et al. Riskfactor of severe preeclampsia in Dr. Soetomo Hospital Surabaya in 2015. Majalah Obstetri & Ginekologi, Vol. 25 No. 1 April 2017: 6-9.
Baker A, Haeri S. Estimating risk factors for development of preeclampsia in teen mothers. Archivesof Gynecology and Obstetrics. 2012;286(5):1093-1096.
El Shahat AM, Ahmed AB, Ahmed MR, Mohamed HS. 2013. Maternal
serum leptin as a marker of preeklampsia. Arch Gynecol Obstet 288(6):1317-1322.
Munawarah et al. Hubungan anatar preeklamsia dan anemia ibu hamil dengan berat bayi lahir rendah. Wellness and Healthy Megazine. 2019. Volume 1. No 02. P 157-167.
Sembiring et al. Pregnancy Induced Hypertension Accompanied With Anemia: Potential Stunting of Newborns. Global Journal of Health Science; Vol. 10, No. 6; 2018.
Ali AA, et al. Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan. BMC Research Notes. 2011, 4:311.
Rohilla M., Ravveendran.A., Dhaliwal.L.K. 2010. Severe Anaemia in Pregnancy a Tertiary Hospital Experience from Northern India. Journal of Obstertrics and Gynaecology 30:694-696.
Lai et al. Systolic, Diastolic and Mean Arterial Pressure at 30–33 Weeks in the Prediction of Preeclampsia. 2013. Fetal Diagn Ther. p. 11015–3837.
Kumari et al. A Comparative Study of Blood Pressure in Normal and Pregnancy Induced Hypertensive Cases for Early Diagnosis of Hypertensive Disorders in A Tertiary Care Hospital. International Journal of Scientific Study. June 2014. Vol 2. Issue 3.
Loho, I. K. A., Rambert, G. I. & Wowor, M. F. Gambaran kadar ureum pada pasien penyakit ginjal kronik stadium 5 non dialisis. J. e-Biomedik 4, (2016).
Yesmin et al. Evaluation of serum ferritin concentration in mild and severe preeclamptic woman. Mymensingh med J. 2016. (1):119-25.
Mannaerts D, Faes E, Cos P, Briede ´ JJ, Gyselaers W, Cornette J, et al. (2018) Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PLoS ONE 13(9): e0202919.
Paul R, et al. Association between serum ferritin and preeclampsia. Bangladesh Med J. 2018 Sept; 47(3).
Gutierrez-Aguirre CS et al. Comparartive analysis of iron status and other hematological parameters in preeclampsia. Hematology, 2017; 22:1, 36-40.
Laila, et al. Serum ferritin in preeclampsia and eclampsia: a case control study. Faridpur med coll journal. 2013; 8(1): 18-21.
D’Souzaa, Vidya Patila, Hemlata Pisala, Karuna Randhira, Asmita Joshia, Savita Mehendaleb, Girija Waghb, Sanjay Guptec, Sadhana Joshia, 2014. Levels of brain derived neurotrophic factors across gestation inwomen with preeklampsia. Int. J. Devl Neuroscience 37. Hal 36–40.
M. Dhobale. Neurotrophic Factors and Maternal Nutrition During Pregnanc. BioTRaK Research and Diagnostics Centre, Navi Mumbai, India.Elsevier, 2017. Volume 104, ISSN 0083-6729.
Lee R, P. Kermani, K.K. Teng, B.L. Hempstead. Regulation of cell survival by secreted proneurotropins, Science 2001, 294 (5548).
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