Correlation of Brain Derived Neurotrophic Factors (BDNF) With Maternal and Perinatal Outcome in Preeclampsia
(1) Hasanuddin Damrah Manna District Hospital, South Bengkulu, Bengkulu, Indonesia
(2) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(3) Sub Division of Maternal Fetal Medicine, Obstetrics and Gynecology Department, Faculty of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
(*) Corresponding Author
DOI: https://doi.org/10.25077/aoj.5.2.148-160.2021
Abstract
Objective: To analyze the correlation between BDNF and maternal and perinatal outcomes in preeclampsia.
Methods: This was an observational analytic study with a cross-sectional design on 73 pregnant women with preeclampsia. The study began in January 2020 to June 2020 in the Obstetrics and Gynecology Department of Dr M. Djamil Hospital Padang.
Results: The mean BDNF levels of pregnant women with preeclampsia were 519.9 ± 325.4 pg/ml. The correlation between BDNF and systolic blood pressure, diastolic blood pressure, and Mean Arterial Pressure was negatively correlated (r = -0.145, -0.1, and -0.218), with a weak correlation. There was no statistically significant relationship between BDNF and systolic blood pressure, diastolic blood pressure, and mean arterial pressure (p> 0.05). BDNF correlation with infant birth weight and the birth length was positively correlated (0.196 and 0.205) with a weak correlation. The correlation between BDNF level and Apgar score was negatively correlated (-0.039 and -0.054) with a weak correlation. There was no statistically significant correlation between BDNF with birth weight, birth length, and Apgar score (p> 0.05).
Conclusion: The mean BDNF level in preeclampsia was lower than normal pregnancy, there was a negative correlation between BDNF levels and maternal outcomes in preeclampsia with a weak correlation. There was a positive correlation between BDNF levels and perinatal outcomes (birth weight and birth length) in preeclampsia and there was a negative correlation between BDNF levels and Apgar score in preeclampsia with a weak correlation.
Keywords: Brain Derived Neurotrophic Factors, Preeclampsia, Maternal Outcome, Perinatal Outcome
Full Text:
PDFReferences
Vandita A. D’Souza , Anitha S. Kilari , Asmita A. Joshi , Savita S. Mehendale, Hemlata M. Pisal, and Sadhana R. Joshi. Differential Regulation of Brain Derived Neurotrophic Factor in Term and Preterm Preeklampsia. Reproductive Sciences 2014. 21(2). DOI: 10.1177/1933719113493512 rs.sagepub.com
Fujita, K. Tatsumi, K. Kondoh, E. Chigusa, Y. Mogami, H. Fujii, T. et al. (2011). Differential expression and the antiapoptotic effect of human placental neurotropins and their receptors. Placenta . Fung, J. Gelaye, B.Qiu-Yue Z. Rondon, MB
Vandita D’Souzaa, Vidya Patila, Hemlata Pisala, Karuna Randhira, Asmita Joshia,Savita Mehendaleb, Girija Waghb, Sanjay Guptec, Sadhana Joshia, 2014. Levels of brain derived neurotrophic factors across gestation inwomen with preeklampsia. Int. J. Devl Neuroscience 37. Hal 36–40. ELSEVIER
M. Dhobale. Neurotrophic : Role in Adverse Pregnancy Outcome. International Journal Of Developmental Neuroscience Volume 37. Elsevier, 2014:8– 14.
Darwin Muhammad , Handono Kalim, Djoko Wahono S, Aru W Sudoyo, Fatchiyah. Hypoxia-Inducible Factor-1α Expression Induce Erythropoietin and Vascular Endothelial Growth Factor Expression on Breast Cancer with Anemia. Jurnal Kedokteran Brawijaya 2012. Vol. 27, No. 2.
Nakamura, K. Martin, KC. Jackson, JK. Beppu, K. Chan-Wook,W. & Thiele, CJ. (2006). Brain-Derived Neurotrophic Factor Activation of TrkB Induces Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Factor-1A in Neuroblastoma Cells. American Association for Cancer Research
Frisca, Caroline T. Sardjono,Ferry Sandra. Angiogenesis: Patofisiologi dan Aplikasi Klinis. JKM. Vol.8 No.2 Februari 2009: 174-187
Lungguk Helen Alfian Tanjung, Sri Sulistyowati, Supriyadi Hari R, 2017. The Effect Of Vascular Endothelial Growth Factor 121 Recombinant Against Expression Of Heat Shock Protein 70 In Mice (Mus Musculus) Model Preeklampsia. Https://Eprints.Uns.Ac.Id/32348/1/S501208018_. Pdf
Sahay, AS. Sundrani, DP. & Joshi, SR, 2017. Neurotropins: Role in Plasental Growth and Development. In G. Litwack, Neurotropins. USA: Elsevier. pp. 243-260.
Gardiner, J., Barton, D., Overall, R., Marc, J., 2009. Neurotrophic support and oxidative stress: converging effects in the normal and diseased nervous system. Neuro- scientist 15, 47–61.
Dhobale M, Mehendale S, Pisal H, D’Souza V, Joshi S. Association of brain- derived neurotrophic factor and tyrosine kinase B receptor in pregnancy. Neuroscience. 2012;216:31-37
Luiza Oliveira Perucci, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Karina Braga Gomes, Luci Maria Dusse, Lirlândia Pires Sousa. Decreased plasma concentrations of brain-derived neurotrophic factor in preeklampsia. L.O. Perucci et al. / Clinica Chimica Acta 464, 2017.142–147
Husen, D &Polin, A. 2012. Factors Influencing Maternal Mortality from Severe Preeclampsia and Eclampsia.MajObstetGinekolog Indonesia 2012; 36-2: 90-4
Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005 Mar 12;330(7491):565
Sohlberg S, Stephansson O, Cnattingius S, et al. 2012. Maternal body mass index, height, and risks of preeklampsia. Am J Hypertens 25(1): 120-125.
Kazuhiro Kawamura, Nanami Kawamura, Wataru Sato, Jun Fukuda, Jin Kumagai,and Toshinobu Tanaka.,Brain-Derived Neurotrophic Factor Promotes Implantation and Subsequent Placental Developmentby Stimulating Trophoblast Cell Growth and Survival. Endocrinology 2009.150(8):3774–3782
Rosemary Kraemer, Barbara L. Hempstead. Neurotropin : Mediator Terbaru Angiogenesis. Frontiers in Bioscience 2003 (8): s1181-1186
M. Dhobale. Neurotrophic Factors and Maternal Nutrition During Pregnanc. BioTRaK Research and Diagnostics Centre, Navi Mumbai, India.Elsevier, 2017. Volume 104, ISSN 0083-6729
Lisa M. Christian, Amanda M. Mitchell, Shannon L. Gillespie, and Marilly Palettas. Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: Associations with race, depressive symptoms, and low birth weight. Psychoneuroendocrinology. 2016 December ; 74: 69–76. doi:10.1016/j.psyneuen.2016.08.025.
I-Te Lee, Wayne Huey-Herng Sheu, Wen-Jane Lee , Der-Yuan Chen. Serum brain- derived neurotrophic factor predicting reduction in pulse pressure after a one-hour rest in nurses working night shifts. Scientific Reports volume 8, https://doi.org/10.1038/s41598-018-23791-8
Helmo, Fernanda Rodrigues. Et.al. Angiogenic and antiangiogenic factors in preeklampsia. Pathology - Research and Practice. Elsevier. 2018
Puchner AM, Nikolaou KE, Economou E, Boutsikou M, Boutsikou T, Kyriakakou. M. Intrauterine growth restriction and circulating neurotrophin levels at term. Early Human Development 2007;83:465-9.
Ardiani Y, Defrin, Husna Yetti, 2019. Kajian Pustaka: Kadar Brain Derived Neurotrophic Factor Mempengaruhi Berat Badan Lahir pada Bayi. Jurnal Ilmiah Universitas Batanghari Jambi Volume 19, Nomor 1, Februari; Hal 152-155
Flöcka, S.K. Weber a, N. Ferrari b, C. Fietz b, C. Graf b, R. Fimmers c, U. Gembrucha, W.M. Merz. Determinants of brain-derived neurotrophic factor (BDNF) in umbilical cord and maternal serum A. Psychoneuroendocrinology 63 (2016) 191–19.
Nitin S. Chouthai, Jackie Sampers, Nirmala Desai, And George M. Smith. Changes In Neurotrophin Levels In Umbilical Cord Blood From Infants With Different Gestational Ages And Clinical Conditions. Pediatric Research 2003 ;Vol. 53, No. 6. Doi: 10.1203/01.Pdr.0000061588.39652.26
M. Dhobale. Neurotrophic Factors and Maternal Nutrition During Pregnanc. BioTRaK Research and Diagnostics Centre, Navi Mumbai, India.Elsevier, 2017. Volume 104, ISSN 0083-6729
S. Mayeur, M. Silhol, Moitrot, S. Barbaux , Breton, A. Gabory ,Vaiman, I. Dutriez- Casteloot, I. Fajardy, A.Vambergue,Tapia-Arancibia, B. Basti, Stormea,B, C. Junien F, D. Vieau A,B, J. Lesage A, 2010. Placental Bdnf/Trkb Signaling System Is Modulated By Fetal Growth Disturbancesin Rat And Human. Placenta 31. Doi 785e791. Elsevier.
Sahay A.S, D.P. Sundrani, G.N. Wagh, S.S. Mehendale , S.R. Joshi. Neurotropin levels in different regions of the placenta and their association with birth outcome and blood pressure. 2015. http://dx.doi.org/10.1016/j.placenta.2015.06.006. Elsevier.
Rudolph, M., Hoffman, E.J., Rudolph, D.C., 2006. Buku Ajar Pediatrik. Edisi 20. EGC. Jakarta.
Refbacks
- There are currently no refbacks.
Address for Correspondence: