A Literature Review : The Role of Genetics in Women of Reproductive Age with Anemia


  • Ida Rahmah Burhan Public Health Department, Faculty of Medicine, Andalas University Padang
  • Delmi Sulastri Department of Nutrition, Faculty of Medicine, Andalas University, Padang




Anemia, Genetic, Iron deficiency, TMPRSS 6, female, age of reproduction.


One of the main nutritional problems in Indonesia is anemia. Iron deficiency anemia can occur due to the interaction of two factors, namely iron intake itself and the role of genetics. The genes in humans and animals involved in iron mechanism is Transmembrane Protease Serine 6 (TMPRSS6). The purpose of this literature review is to determine the role of genetics in reproductive age women with anemia. The search was conducted with Google Schoolar database and Pubmed database looking for articles of the last 10 years from 2012 - 2022. From the number of articles found, only about 10 articles have full criteria. The results of a review of a number of articles found that there is a genetic role in women of reproductive age with anemia associated with the process of iron metabolism with the role of TMPRSS 6 gene mutations that can inhibit hepsidin activation so that it can reduce the ability to absorb iron and have an impact on the occurrence of iron deficiency anemia.


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