Relationship Between Age And Menopausal Status With The Incident Of Epithelial Ovarian Carcinoma At RSUP Dr. M. Djamil Padang

Authors

  • Carmiyana Puja Harsby Student of Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia
  • Syamel Muhammad Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, West Sumatra, Indonesia https://orcid.org/0000-0001-9540-2456
  • Yenita Yenita Department of Anatomical Pathology, Faculty of Medicine, Andalas University, West Sumatra, Indonesia https://orcid.org/0009-0001-2595-5079

DOI:

https://doi.org/10.25077/aoj.10.1.88-96.2026

Keywords:

Age, HGSOC, Menopause Status, Epithelial Ovarian Cancer

Abstract

Introduction : High Grade Serous Ovarian Carcinoma (HGSOC) been the dominant subtype and accounted for the highest mortality rate of epithelial ovarian cancer. Therefore, knowledge of the risk factors for epithelial ovarian cancer was needed for early detection. Age and menopausal status were examples of risk factors. This study aimed to determine the relationship between age and menopausal status with the incidence of epithelial ovarian cancer subtype of HGSOC at M Djamil Central Hospital Padang.

Method : This type of research is an observational analytic research design cross-sectional. The form sample is secondary data used in the total sampling method, which comes from 90 patients of ovarian cancer. Research in analysis univariate and bivariate presented in form table frequency.

Result : In this study, it was found that epithelial ovarian cancers subtype HGSOC was found mostly in women aged > 50 years (68,9%) and who had experienced menopause (80%). In the analytic test, the p value for age and menopausal status was 0.382 and 0.104.

Conclusion: Concluded there is no relationship between age and menopausal status with the incidence of epithelial ovarian cancer subtype HGSOC at M Djamil Central Hospital Padang

Author Biography

Carmiyana Puja Harsby, Student of Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia

Fakultas Kedokteran

References

Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I BF. Ovarian cancer incidence and mortality. International Agency for Research on Cancer (IARC) Globocan. 2020. p. 5–6. doi: 10.1002/ijc.33588

2. American Cancer Society. Cancer facts and figures 2018. American Cancer Society. 2018.

3. Torre L, Trabert B, DeSantis C. Ovarian cancer statistics, 2018. CA Cancer J Clin. 2018;68(4):284–96. doi : 10.3322/caac.21456

4. Globocan. Cancer incident in Indonesia. Vol. 858, International Agency for Research on Cancer. 2020. p. 1–2.

5. Trihandini I, Nurrika D. Analisis ketahanan hidup penderita kanker ovarium epithelial di RS Dharmais Jakarta. J Kesehat Masy Nas. 2010;5(3):139–44. doi: https://doi.org/10.21109/kesmas.v5i3.147

6. Jones PM, Drapkin R. Modeling high-grade serous carcinoma: how converging insights into pathogenesis and genetics are driving better experimental platforms. Front Oncol. 2013;3(217):1–10. doi: 10.3389/fonc.2013.00217

7. Salazar C, Campbell IG, Gorringe KL. When is “type I” ovarian cancer not “type I”? indications of an out-dated dichotomy. Front Oncol. 2018;8(December):1–9. doi: https://doi.org/10.3389/fonc.2018.00654

8. Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C. High-grade serous ovarian cancer: Basic sciences, clinical and therapeutic standpoints. Int J Mol Sci. 2019;20(4). doi: 10.3390/ijms20040952

9. Adisasmita A, Maryani D, Dwipoyono B. Hubungan antara menyusui dengan risiko kanker ovarium. Indones J Cancer. 2016;10(3):93. doi: https://doi.org/10.33371/ijoc.v10i3.437

10. Nurlailiyani. Hubungan antara usia pasien dengan derajat keganasan Tumor ovarium primer di RSUD DR. Moewardi tahun 2011-2012. Instutional Repository UNS. 2013.

11. Dunneram Y, Greenwood DC, Cade JE. Diet, menopause and the risk of ovarian, endometrial and breast cancer. Proc Nutr Soc. 2019;78(3):438–48. doi: 10.1017/S0029665118002884

12. Olsen CM, Green AC, Nagle CM, Jordan SJ, Whiteman DC, Bain CJ, et al. Epithelial ovarian cancer: Testing the “androgens hypothesis.” Endocr Relat Cancer. 2008;15(4):1061–8. doi: https://doi.org/10.1677/ERC-08-0075

13. Nofia D. Analisis faktor yang berhubungan dengan kejadian kanker ovarium tipe epitel di RSUP Dr. M. Djamil Padang tahun 2017-2018 [skripsi]. Padang: Fakultas Kedokteran: Universitas Andalas; 2020.

14. Ardiansyah A. Dasar dasar Onkologi. Surabaya: Airlangga University Press; 2017. 37 p.

15. Murizal TAA, Muhammad S, Nofita E, Mulyani H, Rusjdi SR, Khaira F. Relationship of BMI and parity with high grade serous ovarian cancer at RSUP Dr. M. Djamil Padang. Andalas Obstetrics and Gynecology Journal. 2025;9(2):259–266. doi:10.25077/aoj.9.2.259-266.2025.

16. Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer Biol Med. 2017;14(1):9–32. doi: 10.20892/j.issn.2095-3941.2016.0084

17. Merritt MA, De Pari M, Vitonis AF, Titus LJ, Cramer DW, Terry KL. Reproductive characteristics in relation to ovarian cancer risk by histologic pathways. Hum Reprod. 2013;28(5):1406–17.

18. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: Globoccan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21660

19. Johari B. Insidensi kanker ovarium berdasarkan faktor risiko di RSUP Haji Adam Malik tahun 2008-2011. e-jurnal Fak Kedokt USU. 2013;1(1).

20. Fuh KC, Java JJ, Chan JK, Kapp DS, Monk BJ, Burger RA, et al. Differences In Presentation and Survival of Asians Compared to Caucasians with Ovarian Cancer: An NRG Oncology/GOG Ancillary Study of 7914 Patientes. 2020;154(2):420–5. doi: https://doi.org/10.1016/j.ygyno.2019.05.013

21. Yanti DAM, Sulistianingsih A. Faktor-faktor determinat terjadinya kanker ovarium di RSUD Abdoel Mpelok Provinsi Lampung tahun 2015. J Keperawat. 2016;7(2):79–87.

22. McSorley M, Alberg A, Allen D, Allen N, Brinton L, Dorgan J, et al. Pre-diagnostic circulating follicle stimulating hormone (FSH) concentrations. Bone. 2009;23(1):1–7. doi: 10.1097/01.AOG.0000257126.68803.03

23. Azwan RJ, Muhammad S, Karmia HR. Characteristics of advanced epithelial ovarian cancer patients in Dr. M. Jamil Padang Hospital. Andalas Obstetrics and Gynecology Journal. 2022;9(1):560–568. doi:10.25077/aoj.9.?.560-568.2022

24. Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. Int J Womens Health. 2019;11:287–99. doi: 10.2147/IJWH.S197604

25. Nucci M, Parra-Herran C. Epithelial neoplasms of the ovary. In: Stolnicu S, Fehmi R, editors. Gynecologic Pathology. Elsevier; 2021. p. 577–639.

Downloads

Published

2026-02-02

How to Cite

Harsby, C. P., Muhammad, S., & Yenita, Y. (2026). Relationship Between Age And Menopausal Status With The Incident Of Epithelial Ovarian Carcinoma At RSUP Dr. M. Djamil Padang. Andalas Obstetrics And Gynecology Journal, 10(1), 88–96. https://doi.org/10.25077/aoj.10.1.88-96.2026

Issue

Section

RESEARCH ARTICLE