Correlation of Leukopenia with Vitamin D Levels in Ovarian Cancer Patients Undergoing Platinum-Taxane-Based Chemotherapy

Authors

  • Puja Agung Antonius Gynecological Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University – Dr. M. Djamil Central General Hospital of Padang, Indonesia https://orcid.org/0000-0003-2449-4327
  • Firdawati Firdawati Public Health Division, Faculty of Medicine, Andalas University, Padang, Indonesia https://orcid.org/0000-0002-0894-5047
  • Syamel Muhammad Gynecological Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University – Dr. M. Djamil Central General Hospital of Padang, Indonesia https://orcid.org/0000-0001-9540-2456
  • Yusrawati Yusrawati Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University – Dr. M. Djamil Central General Hospital of Padang, Indonesia https://orcid.org/0000-0002-4799-7202
  • Hudila Rifa Karmia Fetomaternal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University – Dr. M. Djamil Central General Hospital of Padang, Indonesia https://orcid.org/0000-0002-6575-6891
  • Caesar Muhammad Wijaya Gynecological Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University – Dr. M. Djamil Central General Hospital of Padang, Indonesia https://orcid.org/0000-0003-2449-4327

DOI:

https://doi.org/10.25077/aoj.9.2.251-258.2025

Keywords:

Ovarian Cancer, Chemotherapy, Platinum-Taxane, Leukopenia, Vitamin D

Abstract

Introduction: Ovarian cancer is a significant cause of death in women. One of the management of advanced ovarian cancer patients is chemotherapy. The effects of administering Platinum-Taxane-Based chemotherapy to ovarian cancer patients show side effects of myelosuppression, one of which is leukopenia.

Methods: This type of study is a correlation analytical study with a cross-sectional design from October 2023 to May 2024 at Dr. M. Djamil Central General Hospital Padang. The patients included were ovarian cancer patients who underwent Platinum-Taxane-Based chemotherapy with laboratory results of leukopenia.

Results: From 70 patients, it was found that 37 patients (52.9%) had grade I leukopenia, 27 patients (38.6%) had grade II, and 6 patients (8.6%) had grade III. Based on the results obtained, in grade I leukopenia, the average vitamin D value is 13.162 ng/mL, grade II has an average vitamin D value of 11.851 ng/mL, grade III has an average vitamin D value of 14.333 ng/mL. The study results showed a relationship between leukopenia and vitamin D levels p = 0.034 (p < 0.05).

Conclusion: There was a relationship between leukopenia and vitamin D levels in ovarian cancer patients undergoing Platinum-Taxane-Based Chemotherapy at Dr. M. Djamil Central General Hospital Padang.

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Published

2025-07-25

How to Cite

Antonius, P. A., Firdawati, F., Syamel Muhammad, Yusrawati, Y., Karmia, H. R., & Wijaya, C. M. (2025). Correlation of Leukopenia with Vitamin D Levels in Ovarian Cancer Patients Undergoing Platinum-Taxane-Based Chemotherapy . Andalas Obstetrics And Gynecology Journal, 9(2), 251–258. https://doi.org/10.25077/aoj.9.2.251-258.2025

Issue

Vol. 9 No. 2 (2025)

Section

RESEARCH ARTICLE

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Copyright (c) 2025 Puja Agung Antonius, Firdawati Firdawati, Syamel Muhammad, Hudila Rifa Karmia, Caesar Muhammad Wijaya

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