Efficacy of Autologous Platelet-Rich Plasma (PRP) on Perineal Wound Healing: A Controlled Non-Randomized Clinical Trial.
DOI:
https://doi.org/10.25077/aoj.10.1.153-162.2026Keywords:
Perineal wound, PRP, REEDA scaleAbstract
Introduction: Perineal wounds are a very common complication of vaginal birth. Perineal trauma associated with childbirth is defined as damage to the skin, perineal muscles, as well as the sphincter and anal epithelium complex. This study aims to determine the effect of PRP use on perineal wounds.
Method: A single-center, controlled, non-randomized, non-blinded clinical trial was designed in patients with perineal wounds after vaginal delivery. PRP was taken from each patient's serum (autologous). Perineal wound healing after intervention was assessed using the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale. Perineal wound pain was assessed using the Visual Analog Scale (VAS).
Result: The current study involved 56 samples, 28 people per group. The average age of the patients was 28.38 ± 6.280 years. The highest education was high school, 42.9%, while the lowest was elementary school (21.4%). The highest VAS scale was 3 (42.9%) and the lowest was 1 (5.4%). The prevalence of the highest degree of perineal wounds in general was degree 2 (98.2%). The highest score was in the moderately healed group on PRP administration (92.9%). In contrast to the control group, the mildly healed category was 21.4% and not healed 14.4%.
Conclusion: There is a significant relationship between the PRP to healing perineal wounds in vaginal delivery patients at the Seberang Padang Health
References
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21. Tavakoli A, Panchal VR, Mazza GR, others. The association of maternal obesity and obstetric anal sphincter injuries at time of vaginal delivery. AJOG Global Reports. 2023;3(4).
22. Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, Sadat Heidary S, Sepidarkish M. Application of Autologous Platelet-Rich Plasma (PRP) on Wound Healing After Caesarean Section in High-Risk Patients. Iran Red Crescent Med J. 2016 May 17;18(7).
23. Ali H, Sanad A, Khalifa E, Mahran A. Role of Autologous Platelet-Rich Plasma Solution in healing of episotomy After normal vaginal delivary. Minia Journal of Medical Research. 2023;0(0):0.
24. American College of Obstetricians, Gynecologists. ACOG Practice Bulletin No. 198: Prevention and Management of Obstetric Lacerations at Vaginal Delivery. Obstetrics & Gynecology. 2018;132(3):e87–e102.
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26. Alvarenga MB, Francisco AA, Oliveira SMJ V, Silva FMB, Shimoda GT, Damiani LP. Episiotomy healing assessment: Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale reliability. Rev Lat Am Enfermagem. 2015;23(1):162–8.
27. Yamada A, Takahashi Y, Hirose M, others. Factors associated with perineal pain on the first postnatal day after vaginal delivery: a cross-sectional study of primiparous women. Nagoya J Med Sci. 2024;86(1):52–63.
28. Kabakcı AG, Bozkır MG. Effectiveness of platelet-rich plasma treatment in perineal trauma: a case report. Clin Exp Obstet Gynecol. 2021 Jun 15;48(3).
29. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-rich plasma: New performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):1–36.
30. Streit-Ciećkiewicz D, Kołodyńska A, Futyma-Gabka K, Grzybowska M, Gołacki J, Futyma K. Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review. Int J Environ Res Public Health. 2022;19(9):5284.
31. Sanoulis V, Nikolettos N, Vlahos N. The use of plateletrich plasma in the gynaecological clinical setting. A review. Hell J Obstet Gynecol. 2019;18(3):55–65.
32. Prodromidou A, Zacharakis D, Athanasiou S, Protopapas A, Michala L, Kathopoulis N, et al. The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders. Surg Innov. 2022 Feb 28;29(1):80–7.
33. Gupta S, Paliczak A, Delgado D. Evidence-based indications of platelet-rich plasma therapy. Expert Rev Hematol. 2021 Jan 2;14(1):97–108.
2. Ramar CN, Graham W. Perineal Lacerations. StatPearls [Internet]. 2022;
3. Megadhana IW, Indrawan IGS, Sanjaya INH, Aryana MBD. The prevalence and characteristics of perineal ruptur during vaginal delivery at Sanglah General Hospital and Regional Hospitals in Bali from January 2018 until December 2019 period. Bali Medical Journal. 2022;11(1):356–9.
4. Triyani Y, Wittiarika ID, Hardianto G. Factors Influencing the Process of Perineal Wound Healing in Postpartum Women in Serui Hospital, Papua. Indonesian Midwifery and Health Sciences Journal. 2021;5(4):398–405.
5. Cunningham FG, Leveno KJ, Dashe JS, Hoffman BL, Spong CY, Casey BM. Causes of Obstetrical Hemorrhage. In: Williams Obstetrics. 26th ed. New York: McGraw-Hill Education; 2022. p. 739.
6. Dinas Kesehatan Kota Padang. Profil Kesehatan Kota Padang Tahun 2022. Padang; 2023.
7. Jones K, Webb S, Manresa M, Hodgetts-Morton V, Morris RK. The incidence of wound infection and dehiscence following childbirth-related perineal trauma: A systematic review of the evidence. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019 Sep;240:1–8.
8. Akhoundova F, Schumacher F, Léger M, Berndt S, de Tejada B, Abdulcadir J. Use of Autologous Platelet Rich Plasma (A-PRP) for Postpartum Perineal Repair Failure: A Case Report. J Pers Med. 2022;12(11):1917.
9. Ahmed AB, Thatcher S, Khorsandi J, Ahmed Z, Lee M, Jaouhari A, et al. Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions. J Clin Med. 2025 Dec 3;14(23):8583.
10. Barwijuk M, Pankiewicz K, Gałaś A, Nowakowski F, Sachadel K, J. Jakimiuk A, et al. The application of platelet-rich plasma during laparotomy in patients with gynaecological malignancies improves wound healing and reduces postoperative pain feeling – a single-blind placebo controlled intervention study (preliminary report). Współczesna Onkologia. 2024;28(3):235–41.
11. Elkhouly NI, Elkilani OA, Kolaib HA, Elkhouly RM, Morsi DI. Does Autologous Platelet-Rich Plasma Improve Wound Healing and Pain Perception after Cesarean Section in High-Risk Patients? Gynecol Obstet Invest. 2021;86(4):336–42.
12. Moegni F, Rachman A, Ilyas EI, others. A randomized control trial of platelet-rich plasma in supporting the recovery of postpartum levator ani muscle trauma. Medical Journal of Indonesia. 2022;31(3):186–92.
13. Cakwira H, Mukengere M, Lucien B, others. The clinical characteristics of perineal tears: A study carried out on 14 pregnant women in a tertiary center: Case series. Annals of Medicine and Surgery. 2022;82.
14. Jansson MH, Franzén K, Hiyoshi A, others. Risk factors for perineal and vaginal tears in primiparous women – the prospective POPRACT-cohort study. BMC Pregnancy Childbirth. 2020;20(1).
15. Dendini M, Aldossari SK, AlQassab HA, others. Retrospective Case-Control Study of Extended Birth Perineal Tears and Risk Factors. Cureus. 2024;
16. Laurita Longo V, Odjidja EN, Zanfini BA, others. Risk factors associated with severe perineal lacerations during vaginal delivery: a 10-year propensity score–matched observational study. AJOG Global Reports. 2023;3(2).
17. Mahgoub S, Piant H, Gaudineau A, others. Risk factors for obstetric anal sphincter injuries (OASIS) and the role of episiotomy: A retrospective series of 496 cases. J Gynecol Obstet Hum Reprod. 2019;48(8):657–62.
18. Buhalim MA, Albesher MA, Alsultan NJ, others. People’s Knowledge and Attitudes About Factors That Can Impact Wound Healing in the Eastern Province, Saudi Arabia. Cureus. 2023;
19. D’Souza JC, Monga A, Tincello DG. Risk factors for perineal trauma in the primiparous population during non-operative vaginal delivery. Int Urogynecol J. 2020;31(3):621–5.
20. Shalabna E, Yinon M, Daykan Y, others. The association between BMI, episiotomy, and obstetric anal sphincter injuries (OASIS) in singleton vaginal deliveries. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2024;299:143–7.
21. Tavakoli A, Panchal VR, Mazza GR, others. The association of maternal obesity and obstetric anal sphincter injuries at time of vaginal delivery. AJOG Global Reports. 2023;3(4).
22. Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, Sadat Heidary S, Sepidarkish M. Application of Autologous Platelet-Rich Plasma (PRP) on Wound Healing After Caesarean Section in High-Risk Patients. Iran Red Crescent Med J. 2016 May 17;18(7).
23. Ali H, Sanad A, Khalifa E, Mahran A. Role of Autologous Platelet-Rich Plasma Solution in healing of episotomy After normal vaginal delivary. Minia Journal of Medical Research. 2023;0(0):0.
24. American College of Obstetricians, Gynecologists. ACOG Practice Bulletin No. 198: Prevention and Management of Obstetric Lacerations at Vaginal Delivery. Obstetrics & Gynecology. 2018;132(3):e87–e102.
25. Djusad S, Purwosunu Y, Hidayat F. Relationship between Perineal Body Length and Degree of Perineal Tears in Primigravidas Undergoing Vaginal Delivery with Episiotomy. Obstet Gynecol Int. 2021;2021:1–5.
26. Alvarenga MB, Francisco AA, Oliveira SMJ V, Silva FMB, Shimoda GT, Damiani LP. Episiotomy healing assessment: Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale reliability. Rev Lat Am Enfermagem. 2015;23(1):162–8.
27. Yamada A, Takahashi Y, Hirose M, others. Factors associated with perineal pain on the first postnatal day after vaginal delivery: a cross-sectional study of primiparous women. Nagoya J Med Sci. 2024;86(1):52–63.
28. Kabakcı AG, Bozkır MG. Effectiveness of platelet-rich plasma treatment in perineal trauma: a case report. Clin Exp Obstet Gynecol. 2021 Jun 15;48(3).
29. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-rich plasma: New performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):1–36.
30. Streit-Ciećkiewicz D, Kołodyńska A, Futyma-Gabka K, Grzybowska M, Gołacki J, Futyma K. Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review. Int J Environ Res Public Health. 2022;19(9):5284.
31. Sanoulis V, Nikolettos N, Vlahos N. The use of plateletrich plasma in the gynaecological clinical setting. A review. Hell J Obstet Gynecol. 2019;18(3):55–65.
32. Prodromidou A, Zacharakis D, Athanasiou S, Protopapas A, Michala L, Kathopoulis N, et al. The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders. Surg Innov. 2022 Feb 28;29(1):80–7.
33. Gupta S, Paliczak A, Delgado D. Evidence-based indications of platelet-rich plasma therapy. Expert Rev Hematol. 2021 Jan 2;14(1):97–108.
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2026-02-02
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Fadli, M., Utama, B. I., & Ali, H. (2026). Efficacy of Autologous Platelet-Rich Plasma (PRP) on Perineal Wound Healing: A Controlled Non-Randomized Clinical Trial. Andalas Obstetrics And Gynecology Journal, 10(1), 153–162. https://doi.org/10.25077/aoj.10.1.153-162.2026
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Copyright (c) 2026 Muhammad Fadli, Bobby Indra Utama, Hirowati Ali
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