The Effect of Inositol On Malondialdehyde Serum Levels in Medical Students With PCOS
DOI:
https://doi.org/10.25077/aoj.10.1.117-123.2026Keywords:
PCOS, oxidative stress, malondialdehyde, InositolAbstract
Introduction: Polycystic ovary syndrome involves the endocrine system, metabolic system, as well as the reproductive system contributing to anovulatory infertility. Polycystic ovary syndrome affects 5-20% of reproductive age and 6-12% of adolescents. Oxidative stress is known to play an important role in the pathogenesis of PCOS resulting in excessive formation of ROS (malondialdehyde). ROS can be controlled by the antioxidant inositol and has minimal side effects. To determine the effectivity of inositol antioxidant on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical PCOS.
Methods: This study is a clinical trial research with a pure experimental study design (true experimental design). There were 23 samples for the experimental group and 23 samples for the control group selected by probability sampling. Normality test using Shapiro-Wilk test. Data analysis using Independent T test and Mann Whitney Test.
Results: There was a significant decrease in malondialdehyde serum levels in PCOS students who consumed inositol therapy for 3 months.
Conclusion: There is an effect of inositol antioxidant consumption on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical polycystic ovary syndrome.
References
1. International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. American Society for Reproductive Medicine. 2018:1-201.
2. Mentari FP, Haviz Y, Andani EP. Comparison of Lactobacillus Plantarum, Lactobacillus Mucosae and Lactobacillus Farmicis Bacteria between Polycystic Ovary Syndrome and Non Polycistic Ovary Syndrome Students at Medical Faculty of Andalas Unversity. Andalas Obstetrics and Gynecology Journal. 2024;8(2):732-739. DOI: https://doi.org/10.25077/aoj.8.2.732-745.2024
3. Ismayilova M, Yaya S. “I’m Usually Being My Own Doctor”: Women’s Experiences of Managing Polycystic Ovary Syndrome in Canada. International Health. 2023;15:56-66. DOI: https://doi.org/10.1093/inhealth/ihac028
4. Deswal R, Narwal V, Dang A, Pundir CS. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. Journal Human Reproduction Science. 2020;13(4):261-271. DOI: 10.4103/jhrs.JHRS_95_18
5. Audrey UK, Decanter C, Grysole C, Keller L, Behal H, Silva M, et al. Polycystic Ovary Syndrome Phenotype does not have Impact on Oocyte Morphology. Reproductive Biology and Endocrinology. 2022;20(7):1-13. DOI: https://doi.org/10.1186/s12958-021-00874-2
6. Hardi CU, Haviz Y, Ida RB. The Relationship of Vitamin D to Polycystic Ovary Syndrome (PCOS) Teenagers at Koto Tangah Padang District High School in 2022. Andalas Obstetrics and Gynecology Journal. 2024;8(1):615-631. DOI: https://doi.org/10.25077/aoj.8.1.615-631.2024
7. Kamboj MK, Bonny AE. Polycistic Ovary Syndrome in Adolescence: Diagnosis and Therapeutic Strategies. Translational Pediatrics. 2017;6(4):248-255. DOI: 10.21037/tp.2017.09.11
8. Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 International Evidence-Based Guideline For the Assessment and Management of Polycystic Ovary Syndrome. European Journal of Endocrinology. 2023;189(2):G43-G64. DOI: https://doi.org/10.1093/ejendo/lvad096
9. Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, Pathogenesis, Genetics, & Management of Polycystic Ovary Syndrome in India. Indian Journal of Medical Research. 2019;150(4):333-344. DOI: 10.4103/ijmr.IJMR_1937_17
10. Mohammadi M. Oxidative Stress and Polycystic Ovary Syndrome : A Brief Review. International Journal Previous Medicine. 2019;10(86):1-7. DOI: 10.4103/ijpvm.IJPVM_576_17
11. Uckan K, Demir H, Turan K, Sarikaya E, Demir C. Role of Oxidative Stress in Obese and Non Obese PCOS patients. International Journal of Clinical Practice. 2022;2022:1-9. DOI: 10.1155/2022/4579831
12. Greff D, Juhasz AE, Vansca S, Varadi A, Sipos Z, Szinte J, et al. Inositol in an Effective and Safe Treatment in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Reproductive Biology and Endocrinology. 2023;21(10):1-12. DOI: 10.1186/s12958-023-01055-z
13. Unfer V, Nestler JE, Kamenov ZA, Prapas N, Facchinetti F. Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials. International Journal of Endocrinology. 2016;2016:1-13. DOI: 10.1155/2016/1849162
14. Kalra B, Kalra S, Sharma JB. Inositols and PCOS. Metabolic Endocrinology Journal India. 2016;20(5):720-724. DOI: 10.4103/2230-8210.189231
15. Kamenov Z, Gateva A. Inositols in PCOS. Molecules. 2020;25(23):5566. DOI: 10.3390/molecules25235566
16. Pena AS, et al. Adolescent Polycystic Ovary Syndrome According to the International Evidence-based Guideline. BMC Medicine. 2020;18(72):1-16. DOI: 10.1186/s12916-020-01516-x
17. Barber TM, Franks S. Obesity and Polycystic Ovary Syndrome. Clinical Endocrinology. 2021;95:531-541. DOI: https://doi.org/10.1111/cen.14421
18. Zhao H, Zhang J, Cheng X, Nie X, He B. Insulin Resistance in Polycistic Ovary Syndrome Across Various Tissues: an Updated Review of Pathogenesis, Evaluation, and Treatment. Journal of Ovarian Research. 2023;16(9):1-17. DOI: 10.1186/s13048-022-01091-0
19. Chavez GN, Jaworsky K, Basu A. The Effects of Plant-Derived Phytochemical Compounds and Phytochemical-Rich Diets on Females with Polycistic Ovarian Syndrome: a Scoping Review of Clinical Trials. International Journal of Enviromental Research and Public Health. 2023;20(6534)1-17. DOI: https://doi.org/10.3390/ijerph20156534
20. Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, et al. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. Journal of Clinical Medicine. 2023;12(1454):1-24. DOI: https://doi.org/10.3390/jcm12041454
21. Fahs D, Salloum D, Nasrallah M, Ghazeeri G. Polycystic Ovary Syndrome: Pathophysiology and Controversies in Diagnosis. Diagnostics. 2023:13(1559);1-13. DOI: doi.org/10.3390/diagnostics13091559
22. Adashi EY, Cibula D, Peterson M, Azziz R. The Polycystic Ovary Syndrome: the First 150 Years of Study. American Society for Reproductive Medicine. 2023;4(1):1-13. DOI: https://doi.org/10.1016/j.xfre.2022.12.002
23. Sayutti N, Abu MA, Ahmad MF. PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality. Fronties in Endocrinology. May 2022;13:1-13. DOI: 10.3389/fendo.2022.843867
24. Dinicolantonio JJ, O’Keefe JH. Myo-inositol for Insulin Resistance, Metabolic Syndrome, Polycystic Ovary Syndrome, and Gestasional Diabetes. BMJ. 2022;9(1):e001989. DOI: 10.1136/openhrt-2022-001989
25. Lagana AS, Garzon S, Casarin J, Frachi M, Ghazzi F. Inositol in PCOS: Restoring Fertility Through a Pathophysiology-based Approach. Trends in Endocrinology & Metabolism. 2018;29:768-780. DOI: https://doi.org/10.1016/j.tem.2018.09.001
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Eldisha Nofityari, Mondale Saputra, Hirowati Ali
This work is licensed under a Creative Commons Attribution 4.0 International License.
